Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men
Kelley DS, Siegel D, Vemuri M, Mackey BE
The American journal of clinical nutrition · 110 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- National Institutes of Health
- Gobierno
- Agricultural Research Service
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (RR-024146); National Center for Research Resources (UL1 RR024146); U.S. Department of Agriculture (UL1 RR024146); National Institutes of Health (UL1RR024146); National Institutes of Health (RR024146)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2007-08-01 · Am J Clin Nutr · vol. 86 · número 2 · págs. 324–333
- Editorial
- Elsevier BV
- Citado
- 179 citas · más que el 99% de estudios similares · 11.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health · Lipid metabolism and disorders
- Palabras clave
- docosahexaenoic acid, omega-3 supplementation, hypertriglyceridemia, lipoprotein particle size, VLDL particles, LDL cholesterol, HDL cholesterol, small dense LDL, postprandial lipemia, triglycerides, apolipoproteins, olive oil placebo, cardiovascular health
- MeSH
- humans, hypertriglyceridemia, lipids, docosahexaenoic acids, triglycerides, lipoproteins, lipoproteins, hdl, lipoproteins, ldl, lipoproteins, vldl, placebos, fasting, double-blind method, postprandial period, patient selection, dietary supplements, adult, aged, middle aged, male, cholesterol, ldl
4 autores
- Darshan Singh Kelley🇺🇸 · autor de correspondenciaAgricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; Western Regional Research Center; VA Northern California Health Care System; University of California, Davis
- David Siegel🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; Western Regional Research Center; VA Northern California Health Care System; University of California, Davis
- Madhuri Vemuri🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; Western Regional Research Center; VA Northern California Health Care System; University of California, Davis
- Bruce E. Mackey🇺🇸Agricultural Research Service; United States Department of Agriculture; Western Human Nutrition Research Center; Western Regional Research Center; VA Northern California Health Care System; University of California, Davis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied.
Objective
We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma.
Design
Hypertriglyceridemic men aged 39-66 y (n = 34) participated in a double-blind, randomized, placebo-controlled parallel study. They received no supplements for the first 8 d and received either 7.5 g DHA oil/d (3 g DHA/d) or olive oil (placebo) for the last 90 d. Lipoprotein particle diameters and concentrations were measured by nuclear magnetic resonance spectroscopy.
Results
DHA supplementation for 45 d significantly (P < 0.05) decreased concentrations of fasting triacylglycerol (24%), large VLDL (92%), and intermediate-density lipoproteins (53%) and the mean diameter of VLDL particles (11.1 nm). It elevated concentrations of LDL cholesterol (12.6%), small VLDL particles (133%), and large LDL particles (120%) and the mean diameter of LDL particles (0.6 nm) in fasting plasma. Similar changes were observed for area under the curve for postprandial samples (0-6 h); however, the number of small dense LDL particles decreased significantly (21%), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 d caused no further changes; placebo treatment altered none of the responses tested.
Conclusion
DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and small, dense LDL particles.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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