Bioequivalence of Docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food
Arterburn LM, Oken HA, Hoffman JP, Bailey-Hall E, Chung G, Rom D, Hamersley J, McCarthy D
Lipids · 79 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-08-22 · Lipids · vol. 42 · número 11 · págs. 1011–24
- Editorial
- Wiley
- Citado
- 135 citas · más que el 97% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Edible Oils Quality and Analysis
- Palabras clave
- docosahexaenoic acid, algal oil, bioequivalence, bioavailability, omega-3 fatty acids, dietary supplements, plasma phospholipids, arachidonic acid, eicosapentaenoic acid, docosapentaenoic acid, dose-response relationship, safety and tolerability
- MeSH
- erythrocytes, humans, dietary fats, unsaturated, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, unsaturated, arachidonic acid, phospholipids, capsules, placebos, double-blind method, therapeutic equivalency, dietary supplements, food, fortified, adolescent, adult, aged, middle aged, female, male, eukaryota
8 autores
- Linda M. Arterburn
- Harry A. Oken🇺🇸University of Maryland, Baltimore
- James P. Hoffman · autor de correspondencia
- Eileen Bailey‐Hall
- Gloria H. Chung
- Dror Rom
- Jacqueline Hamersley🇺🇸University of Maryland, Baltimore
- Deanna McCarthy
Resumen
El texto original del estudio, en el idioma en que se publicó.
Docosahexaenoic acid (DHA), a long-chain omega-3 fatty acid, is important for eye and brain development and ongoing visual, cognitive, and cardiovascular health. Unlike fish-sourced oils, the bioavailability of DHA from vegetarian-sourced (algal) oils has not been formally assessed. We assessed bioequivalence of DHA oils in capsules from two different algal strains versus bioavailability from an algal-DHA-fortified food. Our 28-day randomized, placebo-controlled, parallel group study compared bioavailability of (a) two different algal DHA oils in capsules ("DHASCO-T" and "DHASCO-S") at doses of 200, 600, and 1,000 mg DHA per day (n = 12 per group) and of (b) an algal-DHA-fortified food (n = 12). Bioequivalence was based on changes in plasma phospholipid and erythrocyte DHA levels. Effects on arachidonic acid (ARA), docosapentaenoic acid-n-6 (DPAn-6), and eicosapentaenoic acid (EPA) were also determined. Both DHASCO-T and DHASCO-S capsules produced equivalent DHA levels in plasma phospholipids and erythrocytes. DHA response was dose-dependent and linear over the dose range, plasma phospholipid DHA increased by 1.17, 2.28 and 3.03 g per 100 g fatty acid at 200, 600, and 1,000 mg dose, respectively. Snack bars fortified with DHASCO-S oil also delivered equivalent amounts of DHA on a DHA dose basis. Adverse event monitoring revealed an excellent safety and tolerability profile. Two different algal oil capsule supplements and an algal oil-fortified food represent bioequivalent and safe sources of DHA.
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