Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review
de Munter JS, Hu FB, Spiegelman D, Franz M, van Dam RM
PLoS medicine · 436 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (R01‐CA050385); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK058845); National Cancer Institute (CA50385); National Institute of Diabetes and Digestive and Kidney Diseases (DK58845); National Institutes of Health (CA 50385); National Institutes of Health (DK58845)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2007-08-24 · PLoS Med · vol. 4 · número 8 · pág. e261
- Editorial
- Public Library of Science
- Citado
- 737 citas · más que el 96% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- whole grains, bran, germs, type 2 diabetes, diabetes risk, dietary intake, body mass index, Nurses' Health Study, pooled analysis, weight management, energy balance, cereals, pooled odds ratio, relative risk
- MeSH
- humans, diabetes mellitus, type 2, body weight, diet surveys, risk factors, cohort studies, follow-up studies, prospective studies, dietary fiber, adult, aged, middle aged, female, surveys and questionnaires, edible grain
5 autores
- Jeroen SL de Munter🇺🇸🇳🇱Harvard University; Vrije Universiteit Amsterdam
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Donna L. Spiegelman🇺🇸Harvard University
- MARY M. FRANZ🇺🇸Harvard University
- Rob M. van Dam🇺🇸🇳🇱 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; Vrije Universiteit Amsterdam
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Control of body weight by balancing energy intake and energy expenditure is of major importance for the prevention of type 2 diabetes, but the role of specific dietary factors in the etiology of type 2 diabetes is less well established. We evaluated intakes of whole grain, bran, and germ in relation to risk of type 2 diabetes in prospective cohort studies.
Methods and findings
We followed 161,737 US women of the Nurses' Health Studies (NHSs) I and II, without history of diabetes, cardiovascular disease, or cancer at baseline. The age at baseline was 37-65 y for NHSI and 26-46 y for NHSII. Dietary intakes and potential confounders were assessed with regularly administered questionnaires. We documented 6,486 cases of type 2 diabetes during 12-18 y of follow-up. Other prospective cohort studies on whole grain intake and risk of type 2 diabetes were identified in searches of MEDLINE and EMBASE up to January 2007, and data were independently extracted by two reviewers. The median whole grain intake in the lowest and highest quintile of intake was, respectively, 3.7 and 31.2 g/d for NHSI and 6.2 and 39.9 g/d for NHSII. After adjustment for potential confounders, the relative risks (RRs) for the highest as compared with the lowest quintile of whole grain intake was 0.63 (95% confidence interval [CI] 0.57-0.69) for NHSI and 0.68 (95% CI 0.57-0.81) for NHSII (both: p-value, test for trend <0.001). After further adjustment for body mass index (BMI), these RRs were 0.75 (95% CI 0.68-0.83; p-value, test for trend <0.001) and 0.86 (95% CI 0.72-1.02; p-value, test for trend 0.03) respectively. Associations for bran intake were similar to those for total whole grain intake, whereas no significant association was observed for germ intake after adjustment for bran. Based on pooled data for six cohort studies including 286,125 participants and 10,944 cases of type 2 diabetes, a two-serving-per-day increment in whole grain consumption was associated with a 21% (95% CI 13%-28%) decrease in risk of type 2 diabetes after adjustment for potential confounders and BMI.
Conclusions
Whole grain intake is inversely associated with risk of type 2 diabetes, and this association is stronger for bran than for germ. Findings from prospective cohort studies consistently support increasing whole grain consumption for the prevention of type 2 diabetes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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