Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study
Costabile A, Klinder A, Fava F, Napolitano A, Fogliano V, Leonard C, Gibson GR, Tuohy KM
The British journal of nutrition · 301 citas
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Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Reading
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-08-29 · Br J Nutr · vol. 99 · número 1 · págs. 110–120
- Editorial
- Cambridge University Press
- Citado
- 444 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Food composition and properties · Gut microbiota and health · Microbial Metabolites in Food Biotechnology
- Palabras clave
- whole wheat, breakfast cereals, prebiotic activity, gut microbiota, wheat bran, Bifidobacterium, lactobacilli, ferulic acid, short-chain fatty acids, total cholesterol
- MeSH
- intestines, ht29 cells, feces, humans, bifidobacterium, triticum, dna damage, coumaric acids, cholesterol, insulin, blood glucose, fatty acids, volatile, triglycerides, dna, bacterial, comet assay, in situ hybridization, fluorescence, analysis of variance, cross-over studies, double-blind method, dietary fiber, foods, specialized, adult, female, male, cholesterol, hdl
8 autores
- Adele Costabile🇬🇧 · autor de correspondenciaUniversity of Reading
- Annett Klinder🇬🇧University of Reading
- Francesca Fava🇬🇧University of Reading
- Aurora Napolitano🇮🇹University of Naples Federico II
- Vincenzo Fogliano🇮🇹University of Naples Federico II
- Clare Leonard
- Glenn R. Gibson🇬🇧University of Reading
- Kieran Michael Tuohy🇬🇧University of Reading
Resumen
El texto original del estudio, en el idioma en que se publicó.
Epidemiological studies have shown an inverse association between dietary intake of whole grains and the risk of chronic disease. This may be related to the ability to mediate a prebiotic modulation of gut microbiota. However, no studies have been conducted on the microbiota modulatory capability of whole-grain (WG) cereals. In the present study, the impact of WG wheat on the human intestinal microbiota compared to wheat bran (WB) was determined. A double-blind, randomised, crossover study was carried out in thirty-one volunteers who were randomised into two groups and consumed daily 48 g breakfast cereals, either WG or WB, in two 3-week study periods, separated by a 2-week washout period. Numbers of faecal bifidobacteria and lactobacilli (the target genera for prebiotic intake), were significantly higher upon WG ingestion compared with WB. Ingestion of both breakfast cereals resulted in a significant increase in ferulic acid concentrations in blood but no discernible difference in faeces or urine. No significant differences in faecal SCFA, fasting blood glucose, insulin, total cholesterol (TC), TAG or HDL-cholesterol were observed upon ingestion of WG compared with WB. However, a significant reduction in TC was observed in volunteers in the top quartile of TC concentrations upon ingestion of either cereal. No adverse intestinal symptoms were reported and WB ingestion increased stool frequency. Daily consumption of WG wheat exerted a pronounced prebiotic effect on the human gut microbiota composition. This prebiotic activity may contribute towards the beneficial physiological effects of WG wheat.
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