Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth
Ship JA, McCutcheon JA, Spivakovsky S, Kerr AR
Journal of oral rehabilitation · 59 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- York University
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-02-22 · J Oral Rehabil · vol. 34 · número 10 · págs. 724–732
- Editorial
- Wiley
- Citado
- 126 citas · más que el 86% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 78 trabajos
- Acceso
- De pago
- Áreas de investigación
- Salivary Gland Disorders and Functions · HIV/AIDS oral health manifestations · Oral health in cancer treatment
- Palabras clave
- xerostomia, polypharmacy, salivary gland hypofunction, olive oil, betaine, xylitol, toothpaste, mouthwash, salivary flow rate, quality of life, older adults, drug-induced dry mouth
- MeSH
- humans, xerostomia, xylitol, betaine, plant oils, mouthwashes, drug combinations, treatment outcome, polypharmacy, severity of illness index, cross-over studies, single-blind method, quality of life, aged, middle aged, female, male, toothpastes, olive oil
4 autores
- Jonathan A. Ship🇺🇸 · autor de correspondenciaNew York University
- Jane A McCutcheon🇺🇸New York University
- Silvia E. Spivakovsky🇺🇸New York University
- Alexander Ross Kerr🇺🇸New York University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Polypharmacy is a common cause of salivary hypofunction, producing symptoms of dry mouth or xerostomia, especially among older populations. As the number of older people continues to increase, polypharmacy-induced salivary hypofunction is becoming an increasing problem. Many over-the-counter products are available for relieving symptoms of dry mouth, but few have been tested in controlled clinical investigations. The purpose of this investigation was to evaluate the safety and efficacy of a group of topical dry mouth products (toothpaste, mouth rinse, mouth spray and gel) containing olive oil, betaine and xylitol. Forty adults were entered into this single-blinded, open-label, cross-over clinical study and 39 completed all the visits. Subjects were randomly assigned at baseline to using the novel topical dry mouth products daily for 1 week, or to maintain their normal dry mouth routine care. After 1 week, they were crossed over to the other dry mouth regimen. The results demonstrated that the use of the novel topical dry mouth products increased significantly unstimulated whole salivary flow rates, reduced complaints of xerostomia and improved xerostomia-associated quality of life. No clinically significant adverse events were observed. These data suggest that the daily use of topical dry mouth products containing olive oil, betaine and xylitol is safe and effective in relieving symptoms of dry mouth in a population with polypharmacy-induced xerostomia.
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