Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents
Chel V, Wijnhoven HA, Smit JH, Ooms M, Lips P
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 125 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Vanderbilt University Medical Center
- Gobierno
- ZonMw
- Universidad u hospital
- Vrije Universiteit Amsterdam
Según 3 financiadores declarados.
Publicación
- Publicado
- 2007-09-13 · Osteoporos Int · vol. 19 · número 5 · págs. 663–671
- Editorial
- Springer Science+Business Media
- Citado
- 203 citas · más que el 98% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Parathyroid Disorders and Treatments
- Palabras clave
- vitamin D3 supplementation, dosing frequency, 25-hydroxyvitamin D, parathyroid hormone, bone turnover markers, calcium supplementation, nursing home residents, older adults, vitamin D status
- MeSH
- humans, bone resorption, vitamin d deficiency, hyperparathyroidism, secondary, calcium, parathyroid hormone, vitamin d, administration, oral, drug administration schedule, bone density, dose-response relationship, drug, dietary supplements, aged, aged, 80 and over, homes for the aged, female, male, bone density conservation agents, statistics as topic
5 autores
- Victor G. M. Chel
- Hanneke A. H. Wijnhoven🇳🇱Amsterdam Public Health; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Johannes H. Smit🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- M. Ooms🇳🇱Amsterdam Public Health; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Paul T.A.M. Lips🇳🇱 · autor de correspondenciaAmsterdam Public Health; Amsterdam UMC Location Vrije Universiteit Amsterdam
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
The effect of equivalent oral doses of vitamin D3 600 IU/day, 4200 IU/week and 18,000 IU/month on vitamin D status was compared in a randomized clinical trial in nursing home residents. A daily dose was more effective than a weekly dose, and a monthly dose was the least effective.
Introduction
It is assumed that equivalent daily, weekly or monthly doses of vitamin D3 equally influence vitamin D status. This was investigated in a randomized clinical trial in nursing home residents.
Methods
The study was performed in ten nursing homes including 338 subjects (76 male and 262 female), with a mean age of 84 (+/- SD 6.3 years). They received oral vitamin D3 either 600 IU/day, or 4200 IU/week, or 18,000 IU/month or placebo. After 4 months, calcium was added during 2 weeks, 320 mg/day or 640 mg/day or placebo.
Outcome
serum levels of 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and bone turnover markers. Statistical approach: linear multilevel analysis.
Results
At baseline, mean serum 25(OH)D was 25.0 nmol/L (SD 10.9), and in 98%, it was lower than 50 nmol/L. After 4 months, mean serum 25(OH)D levels increased to 62.5 nmol/L (after daily vitamin D3 69.9 nmol/L, weekly 67.2 nmol/L and monthly 53.1 nmol/L, P < 0.001 between groups). Median serum PTH levels decreased by 23% (p < 0.001). Bone turnover markers did not decrease. Calcium supplementation had no effect on serum PTH and bone turnover.
Conclusion
Daily vitamin D was more effective than weekly, and monthly administration was the least effective.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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