A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus
Wright SA, O'Prey FM, McHenry MT, Leahey WJ, Devine AB, Duffy EM, Johnston DG, Finch MB, Bell AL, McVeigh GE
Annals of the rheumatic diseases · 107 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-09-18 · Ann Rheum Dis · vol. 67 · número 6 · págs. 841–848
- Editorial
- BMJ
- Citado
- 152 citas · más que el 93% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Systemic Lupus Erythematosus Research · Antioxidant Activity and Oxidative Stress
- Palabras clave
- systemic lupus erythematosus, omega-3 polyunsaturated fatty acids, fish oil supplementation, endothelial function, disease activity, oxidative stress, flow-mediated dilation, cardiovascular risk
- MeSH
- brachial artery, endothelium, vascular, cell membrane, humans, lupus erythematosus, systemic, nitroglycerin, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, unsaturated, dinoprost, vasodilator agents, ultrasonography, doppler, pulsed, treatment outcome, statistics, nonparametric, double-blind method, regional blood flow, vasodilation, dietary supplements, adult, middle aged, female, male, biomarkers
10 autores
- Stephen Wright🇬🇧 · autor de correspondenciaQueen's University Belfast; Musgrave Park Hospital
- F M O’Prey🇬🇧Queen's University Belfast
- M. McHenry🇬🇧Queen's University Belfast; Musgrave Park Hospital
- William J. Leahey🇬🇧Queen's University Belfast
- Adrian B. Devine🇬🇧Queen's University Belfast
- E M Duffy🇬🇧Queen's University Belfast; University of Ulster
- Dennis Johnston🇬🇧Queen's University Belfast
- Michael B. Finch🇬🇧Queen's University Belfast; Musgrave Park Hospital
- A. L. Bell🇬🇧Queen's University Belfast; Musgrave Park Hospital
- Gary Eugene McVeigh🇬🇧Queen's University Belfast
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the clinical effect of dietary supplementation with low-dose omega-3-polyunsaturated fatty acids on disease activity and endothelial function in patients with systemic lupus erythematosus.
Methods
A 24-week randomised double-blind placebo-controlled parallel trial of the effect of 3 g of omega-3-polyunsaturated fatty acids on 60 patients with systemic lupus erythematosus was performed. Serial measurements of disease activity using the revised Systemic Lupus Activity Measure (SLAM-R) and British Isles Lupus Assessment Group index of disease activity for systemic lupus erythematosus (BILAG), endothelial function using flow-mediated dilation (FMD) of the brachial artery, oxidative stress using platelet 8-isoprostanes and analysis of platelet membrane fatty acids were taken at baseline, 12 and 24 weeks.
Results
In the fish oil group there was a significant improvement at 24 weeks in SLAM-R (from 9.4 (SD 3.0) to 6.3 (2.5), p<0.001); in BILAG (from 13.6 (6.0) to 6.7 (3.8), p<0.001); in FMD (from 3.0% (-0.5 to 8.2) to 8.9% (1.3 to 16.9), p<0.001) and in platelet 8-isoprostanes (from 177 pg/mg protein (23-387) to 90 pg/mg protein (32-182), p = 0.007).
Conclusions
Low-dose dietary supplementation with omega-3 fish oils in systemic lupus erythematosus not only has a therapeutic effect on disease activity but also improves endothelial function and reduces oxidative stress and may therefore confer cardiovascular benefits.
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