Caffeine effects on ERPs and performance in an auditory Go/NoGo task
Barry RJ, Johnstone SJ, Clarke AR, Rushby JA, Brown CR, McKenzie DN
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 48 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-10-02 · Clin Neurophysiol · vol. 118 · número 12 · págs. 2692–2699
- Editorial
- Elsevier BV
- Citado
- 68 citas · más que el 84% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Neural and Behavioral Psychology Studies · Neural dynamics and brain function
- Palabras clave
- caffeine, event-related potentials, arousal, P3b, P1, P2, reaction time (psychology), omission and commission errors
- MeSH
- cerebral cortex, humans, caffeine, central nervous system stimulants, placebos, electroencephalography, acoustic stimulation, brain mapping, double-blind method, mental processes, cognition, auditory perception, psychomotor performance, arousal, reaction time, neuropsychological tests, evoked potentials, adolescent, adult, middle aged, female, male
6 autores
- Robert J. Barry🇦🇺 · autor de correspondenciaUniversity of Wollongong
- Stuart John Johnstone🇦🇺University of Wollongong
- Adam R. Clarke🇦🇺University of Wollongong
- Jacqueline Ann Rushby🇦🇺University of Wollongong
- Christopher R. Brown🇦🇺University of Wollongong
- David N. McKenzie🇦🇺University of Wollongong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Previous research has shown that caffeine produces a general increase in arousal. The present study examined caffeine-induced arousal effects on performance and auditory ERPs. We sought components showing amplitude changes without topography changes, as would be expected of a pure arousal amplification of source activity.
Methods
The effects of a single oral dose of caffeine (250 mg) were examined in a randomised double-blind placebo-controlled repeated-measures cross-over study. Subjects abstained from caffeine for 4h before the testing sessions, which were conducted, in the afternoon, one week apart. A simple auditory Go/NoGo task was used, with a random mix of 75 tones at 1000 Hz and 75 at 1500 Hz. All tones were 60 dB SPL, 50 ms duration (rise/fall time 5 ms), with SOA 1100 ms.
Results
There was a reduction in RT, but no effects on omission or commission errors. The major ERP effects of caffeine were focal rather than global increases in P1, P2 and P3b amplitudes to Go stimuli, with no changes in latency. There were no effects on N1 or N2 to Go stimuli, and no effects on any components in response to NoGo stimuli.
Conclusions
The results suggest that caffeine differentially improves aspects of the processing related to response production and task performance, contrary to the widespread amplification of ERP component amplitudes, and latency reductions, expected of an increase in general arousal.
Significance
These results add auditory ERP data to the list of complex effects of caffeine on brain function and behaviour. They appear to rule out a simple arousal interpretation, and suggest directions for future research.
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