Creatine supplementation reduces plasma levels of pro-inflammatory cytokines and PGE2 after a half-ironman competition
Bassit RA, Curi R, Costa Rosa LF
Amino acids · 77 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universidade de São Paulo
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-10-04 · Amino Acids · vol. 35 · número 2 · págs. 425–431
- Editorial
- Springer Science+Business Media
- Citado
- 120 citas · más que el 95% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Exercise and Physiological Responses · Muscle metabolism and nutrition · Sports Performance and Training
- Palabras clave
- creatine supplementation, inflammatory cytokines, prostaglandin E2, exercise-induced inflammation, interleukin-6, TNF-α, interferon-alpha, IL-1β, carbohydrate supplementation, endurance exercise
- MeSH
- humans, inflammation, creatine, dinoprostone, cytokines, physical endurance, running, swimming, dietary supplements, adult, middle aged
3 autores
- Reinaldo Abunasser Bassit🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- Rui Curi🇧🇷Universidade de São Paulo
- L. F. B. P. Costa Rosa🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The effect of creatine supplementation upon plasma levels of pro-inflammatory cytokines: Interleukin (IL) 1 beta and IL-6, Tumor Necrosis Factor alpha (TNFalpha), and Interferon alpha (INF alpha) and Prostaglandin E(2) (PGE(2)) after a half-ironman competition were investigated.
Methods
Eleven triathletes, each with at least three years experience of participation in this sport were randomly divided between the control and experimental groups. During 5 days prior to competition, the control group (n = 6) was supplemented with carbohydrate (20 g x d(-1)) whereas the experimental group (n = 5) received creatine (20 g x d(-1)) in a double-blind trial. Blood samples were collected 48 h before and 24 and 48 h after competition and were used for the measurement of cytokines and PGE(2).
Results
Forty-eight hours prior to competition there was no difference between groups in the plasma concentrations (pg x ml(-1), mean +/- SEM) of IL-6 (7.08 +/- 0.63), TNFalpha (76.50 +/- 5.60), INF alpha (18.32 +/- 1.20), IL-1 beta (23.42 +/- 5.52), and PGE(2) (39.71 +/- 3.8). Twenty-four and 48 h after competition plasma levels of TNFalpha, INF alpha, IL-1 beta and PGE(2) were significantly increased (P < 0.05) in both groups. However, the increases in these were markedly reduced following creatine supplementation. An increase in plasma IL-6 was observed only after 24 h and, in this case, there was no difference between the two groups.
Conclusion
Creatine supplementation before a long distance triathlon competition may reduce the inflammatory response induced by this form of strenuous of exercise.
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