Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial
MacKenzie T, Comi R, Sluss P, Keisari R, Manwar S, Kim J, Larson R, Baron JA
Metabolism: clinical and experimental · 53 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-12-01 · Metabolism · vol. 56 · número 12 · págs. 1694–1698
- Editorial
- Elsevier BV
- Citado
- 82 citas · más que el 91% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Diet, Metabolism, and Disease · Circadian rhythm and melatonin
- Palabras clave
- caffeine, insulin sensitivity, insulin, glucose metabolism, cortisol, dehydroepiandrosterone, androstenedione, salivary melatonin, type 2 diabetes risk, coffee, green tea
- MeSH
- salivary glands, humans, melatonin, caffeine, androstenedione, dehydroepiandrosterone, hydrocortisone, insulin, blood glucose, central nervous system stimulants, cross-over studies, double-blind method, adult, female, male
8 autores
- Todd A. MacKenzie🇺🇸 · autor de correspondenciaDartmouth College; Dartmouth Health
- Richard J. Comi🇺🇸Dartmouth College; Dartmouth Health
- Patrick M. Sluss🇺🇸Harvard University
- Ronit Keisari🇺🇸Dartmouth College; Dartmouth Health
- Simone Manwar🇺🇸Dartmouth College; Dartmouth Health
- Janice Kim🇺🇸Dartmouth College; Dartmouth Health
- Robin J. Larson🇺🇸Dartmouth College; Dartmouth Health
- John A. Baron🇺🇸Dartmouth College; Dartmouth Health
Resumen
El texto original del estudio, en el idioma en que se publicó.
In short-term studies, caffeine has been shown to increase insulin levels, reduce insulin sensitivity, and increase cortisol levels. However, epidemiological studies have indicated that long-term consumption of beverages containing caffeine such as coffee and green tea is associated with a reduced risk of type 2 diabetes mellitus. There is a paucity of randomized studies addressing the metabolic and hormonal effects of consuming caffeine over periods of more than 1 day. We evaluated the effect of oral intake of 200 mg of caffeine taken twice a day for 7 days on glucose metabolism, as well as on serum cortisol, dehydroepiandrosterone (DHEA), and androstenedione, and on nighttime salivary melatonin. A double-blind, randomized, placebo-controlled crossover study with periods of 7 days and washouts of 5 days comparing caffeine with placebo capsules was conducted. Participants were 16 healthy adults aged 18 to 22 years with a history of caffeine consumption. Blood samples from each subject were assayed for glucose, insulin, serum cortisol, DHEA, and androstenedione on the eighth day of each period after an overnight fast. Nighttime salivary melatonin was also measured. Insulin levels were significantly higher (by 1.80 microU/mL; 95% confidence interval, 0.33-3.28) after caffeine intake than after placebo. The homeostasis model assessment index of insulin sensitivity was reduced by 35% (95% confidence interval, 7%-62%) by caffeine. There were no differences in glucose, DHEA, androstenedione, and melatonin between treatment periods. This study provides evidence that daily caffeine intake reduces insulin sensitivity; the effect persists for at least a week and is evident up to 12 hours after administration.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.