Financiado en parte por Almond Board of California
Almond consumption reduces oxidative DNA damage and lipid peroxidation in male smokers
Li N, Jia X, Chen CY, Blumberg JB, Song Y, Zhang W, Zhang X, Ma G, Chen J
The Journal of nutrition · 75 citas
Etiquetas de revisión
Alimentación controladaFinanciado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-12-01 · J Nutr · vol. 137 · número 12 · págs. 2717–2722
- Editorial
- Elsevier BV
- Citado
- 111 citas · más que el 96% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Phytochemicals and Antioxidant Activities
- Palabras clave
- almond consumption, smoking, oxidative stress, oxidative DNA damage, lipid peroxidation, 8-hydroxy-2'-deoxyguanosine, malondialdehyde, antioxidant enzymes, superoxide dismutase, glutathione peroxidase, catalase, alpha-tocopherol, dietary supplementation
- MeSH
- humans, prunus, dna damage, cotinine, vitamin e, antioxidants, diet, smoking, lipid peroxidation, oxidative stress, adult, male, biomarkers
9 autores
- Ning Li🇨🇳Chinese Center For Disease Control and Prevention
- Xudong Jia🇨🇳Chinese Center For Disease Control and Prevention
- C.-Y. Oliver Chen🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Jeffrey B. Blumberg🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Yan Song🇨🇳Chinese Center For Disease Control and Prevention
- Wenzhong Zhang🇨🇳Chinese Center For Disease Control and Prevention
- Xiaopeng Zhang🇨🇳Chinese Center For Disease Control and Prevention
- Guansheng Ma🇨🇳Chinese Center For Disease Control and Prevention
- Junshi Chen🇨🇳 · autor de correspondenciaChinese Center For Disease Control and Prevention
Resumen
El texto original del estudio, en el idioma en que se publicó.
Smoking increases the risk of several chronic diseases associated with elevated oxidative stress status. Almonds are a good source of antioxidant nutrients and may diminish smoking-related biomarkers of oxidative stress. We investigated whether almond consumption decreases biomarkers of oxidative stress in young male smokers. We conducted a randomized, crossover clinical trial with 60 healthy male soldiers (18-25 y) who were habitual smokers (5-20 cigarettes/d) and supplemented their diet with 84 g almonds or 120 g pork (to control for calories) daily for 4 wk with a 4-wk washout period between treatment periods. In addition, 30 healthy nonsmoking men were provided the same daily serving of pork as reference comparison. Blood and urine were collected and assessed for biomarkers of oxidative stress. Baseline values of urinary 8-hydroxy-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) and peripheral lymphocyte DNA strand breaks were significantly higher by 185, 64, and 97% in smokers than nonsmokers, whereas activities of plasma superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase were significantly lower by 15, 10, and 9%, respectively. After the almond intervention, serum alpha-tocopherol, SOD, and GPX increased significantly in smokers by 10, 35, and 16%, respectively and 8-OHdG, MDA, and DNA strand breaks decreased significantly by 28, 34, and 23%. In smokers, after almond supplementation, the concentration of 8-OHdG remained significantly greater than in nonsmokers by 98%. These results suggest almond intake can enhance antioxidant defenses and diminish biomarkers of oxidative stress in smokers.
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