Creatine supplementation and physical training in patients with COPD: a double blind, placebo-controlled study
Faager G, Söderlund K, Sköld CM, Rundgren S, Tollbäck A, Jakobsson P
International journal of chronic obstructive pulmonary disease · 36 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2006-12-01 · Int J Chron Obstruct Pulmon Dis · vol. 1 · número 4 · págs. 445–453
- Editorial
- Dove Medical Press
- Citado
- 45 citas · más que el 59% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Muscle metabolism and nutrition · Chronic Obstructive Pulmonary Disease (COPD) Research · Cardiovascular and exercise physiology
- Palabras clave
- creatine supplementation, chronic obstructive pulmonary disease, exercise training, physical performance, dyspnea, quality of life, muscle strength, muscle fatigue, skeletal muscle energy metabolism, pulmonary rehabilitation
- MeSH
- humans, pulmonary disease, chronic obstructive, creatine, forced expiratory volume, treatment outcome, exercise therapy, double-blind method, exercise tolerance, quality of life, dietary supplements, aged, middle aged, female, male
6 autores
- Gun Faager🇸🇪Karolinska University Hospital; Karolinska Institutet
- Karin Söderlund🇸🇪Swedish School of Sport and Health Sciences
- Carl Magnus Sköld🇸🇪Karolinska Institutet
- Siw Rundgren🇸🇪Karolinska Institutet
- Anna Tollbäck🇸🇪Karolinska University Hospital; Karolinska Institutet
- Per Jakobsson🇸🇪Linköping University; Linköping University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Study objectives
Patients with chronic obstructive pulmonary disease (COPD) have low exercise capacity and low content of high energetic phosphates in their skeletal muscles. The aim of the present study was to investigate whether creatine supplementation together with exercise training may increase physical performance compared with exercise training in patients with COPD.
Design
In a randomized, double-blind, placebo-controlled study, 23 patients with COPD (forced expiratory volume in one second [FEV1] < 70% of predicted) were randomized to oral creatine (n = 13) or placebo (n = 10) supplementation during an 8-week rehabilitation programme including exercise training. Physical performance was assessed by Endurance Shuttle Walking Test (ESWT), dyspnea and leg fatigue with Borg CR- 10, quality of life with St George's Respiratory Questionnaire (SGRQ). In addition, lung function test, artery blood gases, grip strength test, muscle strength and fatigue in knee extensors were measured.
Results
COPD patients receiving creatine supplementation increased their average walking time by 61% (ESWT) (p < 0.05) after the training period compared with 48% (p = 0.07) in the placebo group. Rated dyspnea directly after the ESWT decreased significantly from 7 to 5 (p < 0.05) in the creatine group. However, the difference between the groups was not statistically significant neither in walking time nor in rated dyspnea. Creatine supplementation did not increase the health related quality of life, lung function, artery blood gases, grip strength and knee extensor strength/fatigue.
Conclusions
Oral creatine supplementation in combination with exercise training showed no significant improvement in physical performance, measured as ESWT, in patients with COPD compared with exercise training alone.
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