Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status
Taes YE, Marescau B, De Vriese A, De Deyn PP, Schepers E, Vanholder R, Delanghe JR
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 25 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-01-08 · Nephrol Dial Transplant · vol. 23 · número 4 · págs. 1330–1335
- Editorial
- Oxford University Press
- Citado
- 34 citas · más que el 80% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dialysis and Renal Disease Management · Muscle metabolism and nutrition · Clinical Nutrition and Gastroenterology
- Palabras clave
- creatine supplementation, guanidino compounds, chronic kidney disease, hemodialysis, uremic toxins, guanidinoacetic acid, inflammation, C-reactive protein, serum urea
- MeSH
- humans, inflammation, guanidines, creatine, succinates, urea, arginine, glycine, c-reactive protein, prognosis, treatment outcome, renal dialysis, nephelometry and turbidimetry, administration, oral, severity of illness index, follow-up studies, cross-over studies, double-blind method, dose-response relationship, drug, aged, male, renal insufficiency, biomarkers
7 autores
- Youri Taes🇧🇪 · autor de correspondenciaGhent University Hospital
- Bart Marescau🇧🇪University of Antwerp; Institute Born-Bunge
- An S. De Vriese
- Peter Paul De Deyn🇧🇪University of Antwerp; Institute Born-Bunge
- E. Schepers🇧🇪Ghent University Hospital
- Raymond Vanholder🇧🇪Ghent University Hospital
- Joris R. Delanghe🇧🇪Ghent University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Specific guanidino compounds have been described as uraemic toxins and their concentrations are increased in renal failure due to dimished glomerular filtration, whereas the guanidino compound creatine is used as a performance-enhancing substance in athletes. The present study investigates the effects of creatine supplementation on plasma guanidino compounds in a chronic haemodialysis population.
Methods
Twenty male haemodialysis patients were included in a placebo-controlled cross-over trial. Patients were treated with creatine (2 g/day) or placebo during two treatment periods of 4 weeks, separated by a washout of 4 weeks. Plasma guanidino compounds and routine biochemical parameters were determined, as well as the prognostic inflammatory and nutritional index (PINI).
Results
Upon creatine supplementation, guanidinoacetate concentrations decreased by 15%, due to inhibition of creatine synthesis. Concentrations of alpha-keto-delta-guanidinovaleric acid increased three-fold and argininic acid concentrations doubled. Guanidinosuccinate concentrations did not change, but correlated inversely with CRP (r = -0.736; P = 0.001), PINI-score (r = -0.716; P = 0.002) and correlated positively with plasma urea concentration (r = 0.54; P = 0.02).
Conclusions
Creatine supplementation in haemodialysis patients significantly altered the concentration of specific guanidino compounds. Guanidinosuccinate correlated positively with plasma urea and negatively with inflammation markers.
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