Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study
Sakellaris G, Nasis G, Kotsiou M, Tamiolaki M, Charissis G, Evangeliou A
Acta paediatrica (Oslo, Norway : 1992) · 43 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2007-12-11 · Acta Paediatr · vol. 97 · número 1 · págs. 31–34
- Editorial
- Wiley
- Citado
- 64 citas · más que el 66% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 24 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Traumatic Brain Injury and Neurovascular Disturbances · Traumatic Brain Injury Research · Automotive and Human Injury Biomechanics
- Palabras clave
- traumatic brain injury, creatine supplementation, neuroprotection, post-traumatic headache, dizziness, fatigue, children and adolescents, post-traumatic amnesia, ICU length of stay
- MeSH
- humans, brain injuries, dizziness, fatigue, creatine, neuroprotective agents, treatment outcome, length of stay, case-control studies, prospective studies, pilot projects, time factors, adolescent, child, child, preschool, infant, post-traumatic headache
6 autores
- George Sakellaris🇬🇷 · autor de correspondenciaUniversity Hospital of Heraklion
- George Nasis
- Maria Kotsiou🇬🇷Ippokrateio General Hospital of Thessaloniki
- Maria Tamiolaki🇬🇷Ippokrateio General Hospital of Thessaloniki
- Giorgos C. Charissis🇬🇷University Hospital of Heraklion
- Athanasios Evangeliou🇬🇷University Hospital of Heraklion
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
The complex pathobiology of traumatic brain injury (TBI) offers numerous targets for potential neuroprotective agents. We evaluate the clinical benefit after creatine (Cr) administration in children and adolescents.
Methods
A prospective, randomized, comparative, open- labelled pilot study of the possible neuroprotective effect of Cr was carried out on 39 children and adolescents, aged between 1 and 18 years of age, with TBI. The Cr was administered for 6 months, at a dose of 0.4 g/kg in an oral suspension form every day. For categorical variables, we used the Chi-square test to identify differences between controls and cases. Statistical significance was defined as a p-value 0.1.
Results
The administration of Cr to children and adolescents with TBI improved results in several parameters, including duration of post traumatic amnesia (PTA), duration of intubation, intensive care unit stay. Significant improvement was recorded in the categories of headache (p<0.001), dizziness (p=0.005) and fatigue (p<0.001), aspects in all patients. No side effects were seen due to Cr administration.
Conclusion
More specific examinations including brain spectroscopy for in vivo evaluation of Cr can be done, in order to draw conclusions for the optimal duration and manner of Cr supply, as well as its possible role for the prevention of TBI complications, in double blind studies.
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