Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids
Harris WS, Pottala JV, Sands SA, Jones PG
The American journal of clinical nutrition · 143 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Saint Luke's Health System
Según 1 financiador declarado.
Publicación
- Publicado
- 2007-12-01 · Am J Clin Nutr · vol. 86 · número 6 · págs. 1621–1625
- Editorial
- Elsevier BV
- Citado
- 184 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Edible Oils Quality and Analysis
- Palabras clave
- omega-3 fatty acids, fish oil capsules, oily fish consumption, eicosapentaenoic acid, docosahexaenoic acid, red blood cell membrane fatty acids, plasma phospholipids, bioavailability, salmon, albacore tuna, dietary supplementation
- MeSH
- erythrocyte membrane, animals, fishes, humans, cholesterol, docosahexaenoic acids, eicosapentaenoic acid, triglycerides, phospholipids, fish oils, longitudinal studies, adult, middle aged, female
4 autores
- William Stephen Harris🇺🇸 · autor de correspondenciaSaint Luke's Hospital
- James V. Pottala🇺🇸Saint Luke's Hospital
- Scott A Sands🇺🇸Saint Luke's Hospital
- Philip G. Jones🇺🇸Saint Luke's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
n-3 Fatty acids (FAs) have been shown to be beneficial for cardiovascular health. Whether n-3 FAs from oily fish consumed weekly or from fish-oil capsules taken daily are equally bioavailable is not clear.
Objective
The purpose of this study was to compare the rate and extent of enrichment of blood cell membranes [ie, red blood cells (RBCs)] and plasma phospholipids with n-3 FAs from these 2 sources.
Design
Healthy premenopausal female volunteers were randomly assigned to consume a daily average of 485 mg eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids either from 2 servings of oily fish (ie, salmon and albacore tuna) per week or from 1-2 capsules/d.
Results
After 16 wk, EPA+DHA in RBCs in the fish group (n = 11) increased from 4.0 +/- 0.6% of total FAs to 6.2 +/- 1.4%, whereas it rose from 4.3 +/- 1.0% to 6.2 +/- 1.4% in the capsule group (P < 0.0001 for both; NS for group effect). Similar results were observed in plasma phospholipids. EPA+DHA stabilized in the latter after 4 wk but continued to rise through week 16 in RBCs. EPA in RBCs increased significantly (P = 0.01) more rapidly in the fish group than in the capsule group during the first 4 wk, but rates did not differ significantly between groups thereafter. Total FA variances were less in RBCs than in plasma phospholipids (P = 0.04).
Conclusion
These findings suggest that the consumption of equal amounts of EPA and DHA from oily fish on a weekly basis or from fish-oil capsules on a daily basis is equally effective at enriching blood lipids with n-3 FAs.
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