Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D
Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, Reitz R, Salameh W, Ameri A, Tannenbaum AD
The Journal of clinical endocrinology and metabolism · 473 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (M01-RR0-00533); National Center for Research Resources (M01-RR-00533)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2007-12-19 · J Clin Endocrinol Metab · vol. 93 · número 3 · págs. 677–681
- Editorial
- Oxford University Press
- Citado
- 771 citas · más que el 100% de estudios similares · 45.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 23 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Vitamin K Research Studies · Nutrition and Health Studies
- Palabras clave
- vitamin D2, vitamin D3, 25-hydroxyvitamin D, vitamin D status, vitamin D deficiency, vitamin D supplementation, healthy adults
- MeSH
- humans, cholecalciferol, ergocalciferols, vitamin d, double-blind method, adolescent, adult, aged, aged, 80 and over, middle aged, female, male
10 autores
- Michael F. Holick🇺🇸 · autor de correspondenciaBoston University
- Rachael M. Biancuzzo🇺🇸Boston University
- Tai C. Chen🇺🇸Boston University
- Ellen K. Klein🇺🇸Boston University
- Azzie Young🇺🇸Community Health Center
- Douglass Bibuld🇺🇸Community Health Center
- Richard E. Reitz
- Wael Antoine Salameh
- Allen Ameri🇺🇸Boston University
- Andrew D. Tannenbaum🇺🇸Boston University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status.
Objective
Our objective was to determine whether vitamin D2 was less effective than vitamin D3 in maintaining serum 25-hydroxyvitamin D levels or increased the catabolism of 25-hydroxyvitamin D3.
Subjects and design
This was a randomized, placebo-controlled, double-blinded study of healthy adults ages 18-84 yr who received placebo, 1000 IU vitamin D3, 1000 IU vitamin D2, or 500 IU vitamin D2 plus 500 IU vitamin D3 daily for 11 wk at the end of the winter.
Results
Sixty percent of the healthy adults were vitamin D deficient at the start of the study. The circulating levels of 25-hydroxyvitamin D (mean+/-sd) increased to the same extent in the groups that received 1000 IU daily as vitamin D2 (baseline 16.9+/-10.5 ng/ml; 11 wk 26.8+/-9.6 ng/ml), vitamin D3 (baseline 19.6+/-11.1 ng/ml; 11 wk 28.9+/-11.0 ng/ml), or a combination of 500 IU vitamin D2 and 500 IU vitamin D3 (baseline 20.2+/-10.4 ng/ml; 11 wk 28.4+/-7.7 ng/ml). The 25-hydroxyvitamin D3 levels did not change in the group that received 1000 IU vitamin D2 daily. The 1000 IU dose of vitamin D2 or vitamin D3 did not raise 25-hydroxyvitamin D levels in vitamin D-deficient subjects above 30 ng/ml.
Conclusion
A 1000 IU dose of vitamin D2 daily was as effective as 1000 IU vitamin D3 in maintaining serum 25-hydroxyvitamin D levels and did not negatively influence serum 25-hydroxyvitamin D3 levels. Therefore, vitamin D2 is equally as effective as vitamin D3 in maintaining 25-hydroxyvitamin D status.
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