Effects of oral administration of caffeine and D-ribose on mental fatigue
Ataka S, Tanaka M, Nozaki S, Mizuma H, Mizuno K, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y
Nutrition (Burbank, Los Angeles County, Calif.) · 26 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-02-06 · Nutrition · vol. 24 · número 3 · págs. 233–238
- Editorial
- Elsevier BV
- Citado
- 39 citas · más que el 84% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Sleep and Work-Related Fatigue · Muscle metabolism and nutrition
- Palabras clave
- caffeine, D-ribose, mental fatigue, branched-chain amino acids, plasma amino acids, cognitive performance, Uchida-Kraepelin test, Trail Making Test, sleepiness, motivation
- MeSH
- humans, fatigue, caffeine, hydrocortisone, ribose, amino acids, branched-chain, central nervous system stimulants, treatment outcome, administration, oral, cross-over studies, double-blind method, mental processes, task performance and analysis, reaction time, adult, female, male, adrenocorticotropic hormone
12 autores
- Suzuka Ataka🇯🇵Ministry of Education, Culture, Sports, Science and Technology; Osaka City University
- Masaaki Tanaka🇯🇵Ministry of Education, Culture, Sports, Science and Technology; Osaka City University
- Satoshi Nozaki🇯🇵Ministry of Education, Culture, Sports, Science and Technology; Osaka City University
- Hiroshi Mizuma🇯🇵Ministry of Education, Culture, Sports, Science and Technology; Osaka City University
- Kei Mizuno🇯🇵Ministry of Education, Culture, Sports, Science and Technology; Osaka City University
- Tsuyoshi Tahara🇯🇵Ministry of Education, Culture, Sports, Science and Technology; Osaka City University
- Tomohiro Sugino🇯🇵Osaka City University
- Tomoko Shirai
- Yoshitaka Kajimoto
- Hirohiko Kuratsune🇯🇵Kansai University of Welfare Sciences
- Osami Kajimoto🇯🇵Osaka City University; The University of Osaka
- Yasuyoshi Watanabe🇯🇵Ministry of Education, Culture, Sports, Science and Technology; Osaka City University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We examined the effects of administering two different candidate antifatigue substances, caffeine and D-ribose, on mental fatigue.
Methods
In a double-blinded, placebo-controlled, three-way crossover design, 17 healthy volunteers were randomized to oral caffeine (200 mg/d), D-ribose (2000 mg/d), or placebo for 8 d. As fatigue-inducing mental tasks, subjects performed a 30-min Uchida-Kraepelin psychodiagnostic test and a 30-min advanced trail-making test on four occasions.
Results
During the tasks, the task performance of the caffeine group was better than that of the placebo group. However, after the fatigue-inducing tasks, although subjective perception of fatigue, motivation, or sleepiness was not significantly different, plasma branched-chain amino acid levels in the caffeine group were lower than those of the placebo group. Administration of D-ribose had no effect.
Conclusion
Because plasma branched-chain amino acid levels are decreased by mental fatigue, these results suggest that administration of caffeine improved task performance through the enhancement of central nervous system activity without increasing the sensation of fatigue. However, further decreases in branched-chain amino acid levels indicate that caffeine might promote deeper fatigue than placebo. Unfortunately, research subsequent to our study design has shown that D-ribose dosing higher than we used is needed to see a clinical effect and therefore no conclusions can be made from this study as to the efficacy of D-ribose.
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