Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial
Gualano B, Ugrinowitsch C, Novaes RB, Artioli GG, Shimizu MH, Seguro AC, Harris RC, Lancha AH
European journal of applied physiology · 49 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Food and Nutrition Service
Según 2 financiadores declarados.
Publicación
- Publicado
- 2008-01-10 · Eur J Appl Physiol · vol. 103 · número 1 · págs. 33–40
- Editorial
- Springer Science+Business Media
- Citado
- 88 citas · más que el 88% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Biochemical effects in animals
- Palabras clave
- creatine supplementation, renal function, cystatin C, glomerular filtration rate, aerobic exercise, serum creatinine, sodium and potassium, exercise training, athletes
- MeSH
- kidney, humans, potassium, sodium, creatine, creatinine, glomerular filtration rate, exercise, double-blind method, oxygen consumption, dose-response relationship, drug, dietary supplements, adolescent, adult, male
8 autores
- Bruno Gualano🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- Carlos Ugrinowitsch🇧🇷Universidade de São Paulo
- Rafael Batista Novaes🇧🇷Universidade de São Paulo
- Guilherme Giannini Artioli🇧🇷Universidade de São Paulo
- Maria Heloísa Massola Shimizu🇧🇷Universidade de São Paulo
- Antônio Carlos Seguro🇧🇷Universidade de São Paulo
- Roger C. Harris🇬🇧University of Chichester
- Antônio Herbert Lancha🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Creatine (CR) supplementation is commonly used by athletes. However, its effects on renal function remain controversial. The aim of this study was to evaluate the effects of creatine supplementation on renal function in healthy sedentary males (18-35 years old) submitted to exercise training. A randomized, double-blind, placebo-controlled trial was performed. Subjects (n = 18) were randomly allocated to receive treatment with either creatine (CR) ( approximately 10 g day(-1) over 3 months) or placebo (PL) (dextrose). All subjects undertook moderate intensity aerobic training, in three 40-min sessions per week, during 3 months. Serum creatinine, serum and urinary sodium and potassium were determined at baseline and at the end of the study. Cystatin C was assessed prior to training (PRE), after 4 (POST 4) and 12 weeks (POST 12). Cystatin C levels (mg L(-1)) (PRE CR: 0.82 +/- 0.09; PL: 0.88 +/- 0.07 vs. POST 12 CR: 0.71 +/- 0.06; PL: 0.75 +/- 0.09, P = 0.0001) were decreased over time, suggesting an increase in glomerular filtration rate. Serum creatinine decreased with training in PL but was unchanged with training in CR. No significant differences were observed within or between groups in other parameters investigated. The decrease in cystatin C indicates that high-dose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function.
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