Omega-3 fatty acids and supportive psychotherapy for perinatal depression: a randomized placebo-controlled study
Freeman MP, Davis M, Sinha P, Wisner KL, Hibbeln JR, Gelenberg AJ
Journal of affective disorders · 134 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Mental Health
- Gobierno
- NIMH NIH HHS
- Subvenciones
- National Institute of Mental Health (K23 MH066265)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2008-02-22 · J Affect Disord · vol. 110 · número 1-2 · págs. 142–148
- Editorial
- Elsevier BV
- Citado
- 198 citas · más que el 100% de estudios similares · 22.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Maternal Mental Health During Pregnancy and Postpartum · Fatty Acid Research and Health · Treatment of Major Depression
- Palabras clave
- omega-3 fatty acids, perinatal depression, postpartum depression, antenatal depression, eicosapentaenoic acid, docosahexaenoic acid, supportive therapy, depression treatment efficacy
- MeSH
- humans, pregnancy complications, puerperal disorders, depression, postpartum, fatty acids, omega-3, placebos, treatment outcome, combined modality therapy, psychotherapy, psychotherapy, brief, pregnancy, research design, infant, female, major depressive disorder
6 autores
- Marlene P. Freeman🇺🇸 · autor de correspondenciaUniversity of Arizona; The University of Texas Southwestern Medical Center
- Melinda F. Davis🇺🇸University of Arizona; University of Arizona College of Medicine- Phoenix
- Priti Sinha🇺🇸University of Arizona
- Katherine L. Wisner🇺🇸University of Pittsburgh
- Joseph R. Hibbeln🇺🇸National Institute on Alcohol Abuse and Alcoholism
- Alan J. Gelenberg🇺🇸University of Arizona
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Perinatal major depressive disorder (MDD), including antenatal and postpartum depression, is common and has serious consequences. This study was designed to investigate the feasibility, safety, and efficacy of omega-3 fatty acids for perinatal depression in addition to supportive psychotherapy.
Methods
Perinatal women with MDD were randomized to eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), 1.9g/day, or placebo for 8weeks. A manualized supportive psychotherapy was provided to all subjects. Symptoms were assessed with the Hamilton Rating Scale for Depression (HAM-D) and Edinburgh Postnatal Depression Scale (EPDS) biweekly.
Results
Fifty-nine women enrolled; N = 51 had two data collection points that allowed for evaluation of efficacy. Omega-3 fatty acids were well tolerated. Participants in both groups experienced significant decreases in EPDS and HAM-D scores (p<.0001) from baseline. We did not find a benefit of omega-3 fatty acids over placebo. Dietary omega-3 fatty acid intake was low among participants.
Limitations
The ability to detect an effect of omega-3 fatty acids may have been limited by sample size, study length, or dose. The benefits of supportive psychotherapy may have limited the ability to detect an effect of omega-3 fatty acids.
Conclusions
There was no significant difference between omega-3 fatty acids and placebo in this study in which all participants received supportive psychotherapy. The manualized supportive psychotherapy warrants further study. The low intake of dietary omega-3 fatty acids among participants is of concern, in consideration of the widely established health advantages in utero and in infants.
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