Financiado en parte por Pfizer Australia
Omega-3 fatty acids as a treatment for perinatal depression: randomized double-blind placebo-controlled trial
Rees AM, Austin MP, Parker GB
The Australian and New Zealand journal of psychiatry · 96 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- New South Wales Institute of Psychiatry
- Empresa
- Pfizer Australia
Según 2 financiadores declarados.
Publicación
- Publicado
- 2008-01-01 · Aust N Z J Psychiatry · vol. 42 · número 3 · págs. 199–205
- Editorial
- SAGE Publishing
- Citado
- 134 citas · más que el 99% de estudios similares · 12.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Maternal Mental Health During Pregnancy and Postpartum · Fatty Acid Research and Health · Treatment of Major Depression
- Palabras clave
- omega-3 fatty acids, perinatal depression, fish oil supplementation, antidepressant treatment, placebo comparison
- MeSH
- humans, depression, postpartum, fatty acids, omega-3, antidepressive agents, prenatal care, follow-up studies, double-blind method, patient compliance, demography, pregnancy, adult, female, major depressive disorder
3 autores
- Anne-Marie Rees🇦🇺Black Dog Institute; UNSW Sydney; Prince of Wales Hospital
- Marie‐Paule Austin🇦🇺Royal Hospital for Women; UNSW Sydney
- Gordon Barraclough Parker🇦🇺Black Dog Institute; UNSW Sydney; Prince of Wales Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Epidemiological, biological marker and treatment studies, as well as neuroscientific theories, indicate a possible link between omega-3 fatty acids and perinatal depression (PND). Hence the aim of the present study was to assess whether omega-3 fatty acid treatment is superior to placebo in the treatment of PND.
Method
A double-blind randomized placebo-controlled trial was undertaken. Women with major depression during the perinatal period received either fish oil or placebo for six weeks. Changes in depression scores were recorded weekly.
Results
A total of 26 subjects were recruited and there was no significant difference in depression scores between those receiving fish oil and those receiving the placebo.
Conclusions
This is formally a negative study, suggesting that there is no benefit for omega-3 fatty acids over placebo in treating PND. The reason could be that the study was underpowered due to recruitment difficulties and therefore we suggest that it may be unwise to interpret this result as conclusive. Omega-3 is a natural product that is a safe and well-tolerated treatment. Further research is therefore needed in this area to establish whether omega-3 fatty acids are an effective treatment for PND.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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