Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A
Hypertension (Dallas, Tex. : 1979) · 770 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Subvenciones
- Wellcome Trust (067422)
Según 1 financiador declarado.
Publicación
- Publicado
- 2008-02-04 · Hypertension · vol. 51 · número 3 · págs. 784–790
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 1,075 citas · más que el 100% de estudios similares · 27.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention · Phytochemicals and Antioxidant Activities
- Palabras clave
- dietary nitrate, beetroot juice, blood pressure reduction, nitric oxide, endothelial dysfunction, platelet aggregation, cardiovascular disease
- MeSH
- tongue, endothelium, vascular, saliva, humans, beta vulgaris, hypertension, reperfusion injury, nitrates, nitrites, diet, cross-over studies, platelet aggregation, blood pressure, adolescent, adult, middle aged
13 autores
- Andrew J. Webb🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Nakul Patel🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Stavros Loukogeorgakis🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- M Okorie🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Zainab Aboud🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Shivani Misra🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Rahim A. Rashid🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- P Miall🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- John Eric Deanfield🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Nigel Benjamin🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Raymond J. MacAllister🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Adrian J. Hobbs🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
- Amrita Ahluwalia🇬🇧Queen Mary University of London; William Harvey Research Institute; University College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Diets rich in fruits and vegetables reduce blood pressure (BP) and the risk of adverse cardiovascular events. However, the mechanisms of this effect have not been elucidated. Certain vegetables possess a high nitrate content, and we hypothesized that this might represent a source of vasoprotective nitric oxide via bioactivation. In healthy volunteers, approximately 3 hours after ingestion of a dietary nitrate load (beetroot juice 500 mL), BP was substantially reduced (Delta(max) -10.4/8 mm Hg); an effect that correlated with peak increases in plasma nitrite concentration. The dietary nitrate load also prevented endothelial dysfunction induced by an acute ischemic insult in the human forearm and significantly attenuated ex vivo platelet aggregation in response to collagen and ADP. Interruption of the enterosalivary conversion of nitrate to nitrite (facilitated by bacterial anaerobes situated on the surface of the tongue) prevented the rise in plasma nitrite, blocked the decrease in BP, and abolished the inhibitory effects on platelet aggregation, confirming that these vasoprotective effects were attributable to the activity of nitrite converted from the ingested nitrate. These findings suggest that dietary nitrate underlies the beneficial effects of a vegetable-rich diet and highlights the potential of a "natural" low cost approach for the treatment of cardiovascular disease.
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