Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels
Sugden JA, Davies JI, Witham MD, Morris AD, Struthers AD
Diabetic medicine : a journal of the British Diabetic Association · 386 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Dundee
- Organización sin fines de lucro
- Diabetes UK
Según 2 financiadores declarados.
Publicación
- Publicado
- 2008-02-14 · Diabet Med · vol. 25 · número 3 · págs. 320–325
- Editorial
- Wiley
- Citado
- 554 citas · más que el 100% de estudios similares · 25.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- vitamin D supplementation, vitamin D2, endothelial function, type 2 diabetes, vitamin D insufficiency, 25-hydroxyvitamin D, flow-mediated dilation, brachial artery, systolic blood pressure, winter
- MeSH
- endothelium, humans, diabetes mellitus, type 2, vitamin d deficiency, 25-hydroxyvitamin d 2, vitamin d, blood pressure, dietary supplements, aged, middle aged, female, male, statistics as topic
5 autores
- Jacqui Sugden🇬🇧 · autor de correspondenciaNinewells Hospital
- Justine Ina Davies
- Miles D. Witham
- Andrew D. Morris🇬🇧University of Dundee; Ninewells Hospital
- Allan D. Struthers
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To test whether a single large dose of vitamin D2 can improve endothelial function in patients with Type 2 diabetes mellitus and low serum 25-hydroxyvitamin D levels.
Methods
Double-blind, parallel group, placebo-controlled randomized trial. A single dose of 100,000 IU vitamin D2 or placebo was administered to patients with Type 2 diabetes over the winter, when levels of circulating 25-hydroxyvitamin D were likely to be lowest. Patients were enrolled if their baseline 25-hydroxyvitamin D level was < 50 nmol/l. Endothelial function and blood pressure were measured and fasting blood samples were taken at baseline and 8 weeks after administration of vitamin D.
Results
Forty-nine per cent of subjects screened had 25-hydroxyvitamin D levels < 50 nmol/l. Thirty-four subjects completed the study, with a mean age of 64 years and a baseline 25-hydroxyvitamin D level of 38.3 nmol/l. Vitamin D supplementation increased 25-hydroxyvitamin D levels by 15.3 nmol/l relative to placebo and significantly improved flow mediated vasodilatation (FMD) of the brachial artery by 2.3%. The improvement in FMD remained significant after adjusting for changes in blood pressure. Vitamin D supplementation significantly decreased systolic blood pressure by 14 mmHg compared with placebo; this did not correlate with change in FMD.
Conclusions
Vitamin D insufficiency is common in patients with Type 2 diabetes during winter in Scotland. A single large dose of oral vitamin D2 improves endothelial function in patients with Type 2 diabetes and vitamin D insufficiency.
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