Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis
Zipitis CS, Akobeng AK
Archives of disease in childhood · 374 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-03-14 · Arch Dis Child · vol. 93 · número 6 · págs. 512–517
- Editorial
- BMJ
- Citado
- 662 citas · más que el 95% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Diabetes and associated disorders · Diabetes Management and Research
- Palabras clave
- vitamin D supplementation, type 1 diabetes, infancy, early childhood, dose-response relationship, timing of supplementation, diabetes prevention, observational studies
- MeSH
- humans, diabetes mellitus, type 1, vitamin d deficiency, vitamins, vitamin d, case-control studies, age factors, dose-response relationship, drug, adolescent, child, child, preschool, infant
2 autores
- Christos Steliou Zipitis🇬🇧 · autor de correspondenciaStockport NHS Foundation Trust
- Anthony Kwaku Akobeng
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
To assess whether vitamin D supplementation in infancy reduces the risk of type 1 diabetes in later life.
Methods
This was a systematic review and meta-analysis using Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles. The main outcome measure was development of type 1 diabetes. Controlled trials and observational studies that had assessed the effect of vitamin D supplementation on risk of developing type 1 diabetes were included in the analysis.
Results
Five observational studies (four case-control studies and one cohort study) met the inclusion criteria; no randomised controlled trials were found. Meta-analysis of data from the case-control studies showed that the risk of type 1 diabetes was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented (pooled odds ratio 0.71, 95% CI 0.60 to 0.84). The result of the cohort study was in agreement with that of the meta-analysis. There was also some evidence of a dose-response effect, with those using higher amounts of vitamin D being at lower risk of developing type 1 diabetes. Finally, there was a suggestion that the timing of supplementation might also be important for the subsequent development of type 1 diabetes.
Conclusion
Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes. The evidence for this is based on observational studies. Adequately powered, randomised controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation.
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