Fish oil supplementation in the parenteral nutrition of critically ill medical patients: a randomised controlled trial
Friesecke S, Lotze C, Köhler J, Heinrich A, Felix SB, Abel P
Intensive care medicine · 83 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universität Greifswald
Según 1 financiador declarado.
Publicación
- Publicado
- 2008-03-20 · Intensive Care Med · vol. 34 · número 8 · págs. 1411–1420
- Editorial
- Springer Science+Business Media
- Citado
- 124 citas · más que el 98% de estudios similares · 10.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Palabras clave
- fish oil supplementation, parenteral nutrition, omega-3 fatty acids, systemic inflammatory response syndrome, interleukin-6, monocyte HLA-DR expression, nosocomial infections, mechanical ventilation duration, ICU mortality, critically ill medical patients, medium-chain triglycerides, long-chain triglycerides, bleeding complications
- MeSH
- humans, critical illness, fish oils, interleukin-6, hla-dr antigens, parenteral nutrition, hospital mortality, double-blind method, aged, middle aged, intensive care units, female, male, systemic inflammatory response syndrome
6 autores
- Sigrun Friesecke🇩🇪 · autor de correspondenciaUniversität Greifswald
- Christian Lotze🇩🇪Universität Greifswald
- Jenny Köhler🇩🇪Universität Greifswald
- Annegret Heinrich🇩🇪Universität Greifswald
- Stephan Burkhard Felix🇩🇪Universität Greifswald
- Peter Abel🇩🇪Universität Greifswald
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To test whether supplementation of parenteral nutrition with fish oil - aimed at increasing the n-3:n-6 ratio of polyunsaturated fatty acids (PUFA) to 1:2 - affects systemic inflammation and clinical outcome compared to standard parenteral nutrition with an n-3/n-6 ratio of 1:7 in medical intensive care unit (ICU) patients.
Design
Single-centre, placebo-controlled, double-blind, randomised clinical trial.
Setting
Twelve-bed medical ICU of a university hospital.
Patients
A total of 166 consecutive patients anticipated to need parenteral nutrition for more than 6 days. Patients were stratified for the presence of systemic inflammatory response syndrome (SIRS) at baseline (115 SIRS, 51 non-SIRS).
Intervention
Patients were randomly assigned to receive either a 1:1-mixture of medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) with an n-3/n-6 PUFA ratio of 1:7, or the same MCT/LCT emulsion supplemented with fish oil (resulting in an n-3/n-6 ratio of 1:2).
Measurements and results
Primary endpoints were changes in interleukin 6 (IL-6) and monocyte HLA-DR expression relative to baseline. Secondary endpoints were incidence of nosocomial infections, duration of mechanical ventilation, length of ICU stay, and 28-day mortality. Bleeding complications were recorded as a possible side effect of fish oil. Between standard and intervention groups, overall as well as stratified for SIRS or non-SIRS, no significant difference was detected in any of the endpoints or frequency and severity of bleeding events.
Conclusions
In unselected critically ill medical patients, fish oil supplementation that increased the n-3/n-6 PUFA ratio to 1:2 did not affect inflammation or clinical outcome, compared to parenteral lipid nutrition with an MCT/LCT emulsion.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.