Randomized controlled trial of dietary creatine as an adjunct therapy to physical training in chronic obstructive pulmonary disease
Deacon SJ, Vincent EE, Greenhaff PL, Fox J, Steiner MC, Singh SJ, Morgan MD
American journal of respiratory and critical care medicine · 63 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-07-23 · Am J Respir Crit Care Med · vol. 178 · número 3 · págs. 233–239
- Editorial
- American Thoracic Society
- Citado
- 90 citas · más que el 90% de estudios similares · 2.9× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Muscle metabolism and nutrition · Chronic Obstructive Pulmonary Disease (COPD) Research · Muscle Physiology and Disorders
- Palabras clave
- chronic obstructive pulmonary disease, pulmonary rehabilitation, exercise training, muscle strength, functional exercise capacity, skeletal muscle mass, resistance training, shuttle walk test, creatine uptake, body composition
- MeSH
- humans, pulmonary disease, chronic obstructive, creatine, exercise test, vital capacity, forced expiratory volume, treatment outcome, exercise, exercise therapy, exercise tolerance, dietary supplements, aged, middle aged, female, male, muscle strength
7 autores
- Sarah J. Deacon🇬🇧Glenfield Hospital; University Hospitals of Leicester NHS Trust
- Emma E. Vincent🇬🇧Glenfield Hospital; University Hospitals of Leicester NHS Trust
- Paul Leonard Greenhaff🇬🇧University of Nottingham; Queen's Medical Centre
- John Fox🇬🇧University of Nottingham; Queen's Medical Centre
- MICHAEL C. STEINER🇬🇧Glenfield Hospital; University Hospitals of Leicester NHS Trust
- Sally J. Singh🇬🇧Glenfield Hospital; University Hospitals of Leicester NHS Trust
- Michael D.L. Morgan🇬🇧Glenfield Hospital; University Hospitals of Leicester NHS Trust
Resumen
El texto original del estudio, en el idioma en que se publicó.
Rationale
Skeletal muscle strength and bulk are reduced in patients with chronic obstructive pulmonary disease (COPD) and influence quality of life, survival, and utilization of health care resources. Exercise training during pulmonary rehabilitation (PR) can reverse some of these effects. In athletes and healthy elderly individuals, dietary creatine supplementation (CrS) has been shown to augment high-intensity exercise training, thereby increasing muscle mass.
Objectives
This article examines the effect of CrS on functional exercise capacity and muscle performance in people with COPD.
Methods
One hundred subjects with COPD (mean [SD] age, 68.2 [8.2] yr; FEV(1), 44.0 [19.6] %predicted) were randomized to a double-blind, placebo-controlled, parallel group trial of CrS during 7 weeks of PR encompassing aerobic and resistance exercises. Subjects ingested creatine (22 g/d loading for 5 d; maintenance, 3.76 g/d throughout PR) or placebo. Baseline, postloading, and postrehabilitation measurements included pulmonary function, body composition, peripheral muscle strength, and functional performance (shuttle walking tests). A volunteer subgroup (n = 44) had pre- and postloading quadriceps muscle biopsies.
Measurements and main results
Eighty subjects completed the trial (38 creatine, 42 placebo). All outcome measures significantly improved after PR. There were no significant differences between groups post-PR (mean [SD] change in incremental shuttle walk distance, 84 [79] m in the creatine group vs. 83.8 [60] m in the placebo group; P = 1.0; knee extensor work, 19.2 [16] Nm [Newton meters] in the creatine group vs. 19.5 [17] Nm in the placebo group; P = 0.9). Muscle biopsies showed evidence of creatine uptake.
Conclusions
This adequately powered, randomized, placebo-controlled trial shows that CrS does not augment the substantial training effect of multidisciplinary PR for patients with COPD. Clinical trial registered with https://portal.nihr.ac.uk/Pages/NRRArchiveSearch.aspx (NO123138126).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.