Omega-3 fatty acids-supplemented parenteral nutrition decreases hyperinflammatory response and attenuates systemic disease sequelae in severe acute pancreatitis: a randomized and controlled study
Wang X, Li W, Li N, Li J
JPEN. Journal of parenteral and enteral nutrition · 106 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (30500404)
Según 1 financiador declarado.
Publicación
- Publicado
- 2008-05-01 · JPEN J Parenter Enteral Nutr · vol. 32 · número 3 · págs. 236–241
- Editorial
- Wiley
- Citado
- 150 citas · más que el 99% de estudios similares · 11.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 24 trabajos
- Acceso
- De pago
- Áreas de investigación
- Pancreatitis Pathology and Treatment · Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health
- Palabras clave
- omega-3 fatty acids, fish oil, parenteral nutrition, severe acute pancreatitis, hyperinflammatory response, eicosapentaenoic acid, interleukin-6, C-reactive protein, continuous renal replacement therapy, respiratory function, lipid emulsion composition, systemic inflammatory response
- MeSH
- humans, pancreatitis, acute disease, inflammation, fatty acids, omega-3, eicosapentaenoic acid, soybean oil, fish oils, c-reactive protein, interleukin-6, leukocyte count, treatment outcome, parenteral nutrition, peritoneal dialysis, continuous ambulatory, length of stay, adolescent, adult, aged, aged, 80 and over, middle aged, female, male
4 autores
- Xinying Wang🇨🇳Nanjing General Hospital of Nanjing Military Command
- Weiqin Li🇨🇳Nanjing General Hospital of Nanjing Military Command
- Ning Li🇨🇳Nanjing General Hospital of Nanjing Military Command
- Jieshou Li🇨🇳 · autor de correspondenciaNanjing General Hospital of Nanjing Military Command
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The objective of this study was to investigate whether altering the fatty acid (FA) profile by omega-3 FA supplementation affects inflammatory response and systemic disease sequelae in severe acute pancreatitis.
Methods
Forty severe acute pancreatitis patients were enrolled and randomly assigned to receive parenteral nutrition (PN) for 5 days in a double-blind manner. Patients received PN with identical amounts of amino acids (1.25 g/kg/d), glucose (3 g/kg/d), and fat (1 g/kg/d) but different lipid compositions: the control group received a soybean oil (SO; Lipovenos 20%; Fresenius, Germany)-based fat solution and the omega-3 FA group was supplemented with 0.15 - 0.2 g/kg/d fish oil (FO; Omegaven 10%; Fresenius, Germany). Serum concentrations of eicosapentaenoic acid (EPA), interleukin-6, C-reactive protein (CRP), white blood cell count, and routine respiratory and renal parameters were measured before PN, and again on day 6 after starting PN. Outcomes such as infection morbidity, mortality, intensive care unit time, and length of hospital stay were recorded.
Results
Patients treated with FO had a significantly higher EPA concentration (P < .01), lower CRP level (P < .05), and better oxygenation index (P < .05) after 5 days of PN. Moreover, the number of days of continuous renal replacement therapy (CRRT) in the omega-3 FAs group was significantly less than that in the control group (P < .05).
Conclusions
PN supplemented with omega-3 FAs diminishes the hyperinflammatory response by the EPA increase and the proinflammatory cytokine decrease in severe acute pancreatitis. This, together with improved respiratory function and shortened CRRT time, suggests that the systemic response to pancreatic and organ injury is attenuated.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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