Financiado en parte por California Walnut Commission
The effect of walnut intake on factors related to prostate and vascular health in older men
Spaccarotella KJ, Kris-Etherton PM, Stone WL, Bagshaw DM, Fishell VK, West SG, Lawrence FR, Hartman TJ
Nutrition journal · 53 citas
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Pennsylvania State University
- Grupo de la industria
- California Walnut Commission
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of California, Davis
- Universidad u hospital
- University of California, San Francisco
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (M01 RR10732); National Center for Research Resources (M01-RR-010732); National Institutes of Health (M01-RR-10-732)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2008-05-02 · Nutr J · vol. 7 · número 1 · pág. 13
- Editorial
- BioMed Central
- Citado
- 92 citas · más que el 92% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress
- Palabras clave
- Juglans regia, tocopherols, gamma-tocopherol, alpha-tocopherol, prostate-specific antigen, free PSA, prostate cancer risk, cardiovascular disease, triglycerides, older men, dietary supplementation, vascular health
- MeSH
- humans, juglans, prostatic neoplasms, vascular diseases, prostate-specific antigen, triglycerides, tocopherols, alpha-tocopherol, gamma-tocopherol, risk factors, cross-over studies, dietary supplements, aged, middle aged, male, biomarkers
8 autores
- Kim Spaccarotella🇺🇸Rutgers, The State University of New Jersey; Pennsylvania State University
- Penny M. Kris‐Etherton🇺🇸Pennsylvania State University
- William L. Stone🇺🇸East Tennessee State University
- Deborah Maddox Bagshaw🇺🇸Pennsylvania State University
- Valerie K. Fishell🇺🇸Pennsylvania State University
- Sheila G. West🇺🇸Pennsylvania State University
- Frank Lawrence🇺🇸Pennsylvania State University
- Terryl J. Hartman🇺🇸 · autor de correspondenciaPennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Tocopherols may protect against prostate cancer and cardiovascular disease (CVD).
Methods
We assessed the effect of walnuts, which are rich in tocopherols, on markers of prostate and vascular health in men at risk for prostate cancer. We conducted an 8-week walnut supplement study to examine effects of walnuts on serum tocopherols and prostate specific antigen (PSA). Subjects (n = 21) consumed (in random order) their usual diet +/- a walnut supplement (75 g/d) that was isocalorically incorporated in their habitual diets. Prior to the supplement study, 5 fasted subjects participated in an acute timecourse experiment and had blood taken at baseline and 1, 2, 4, and 8 h after consuming walnuts (75 g).
Results
During the timecourse experiment, triglycerides peaked at 4 h, and gamma-tocopherol (gamma-T) increased from 4 to 8 h. Triglyceride - normalized gamma-T was two-fold higher (P = 0.01) after 8 versus 4 h. In the supplement study, change from baseline was +0.83 +/- 0.52 micromol/L for gamma-T, -2.65 +/- 1.30 micromol/L for alpha-tocopherol (alpha-T) and -3.49 +/- 1.99 for the tocopherol ratio (alpha-T: gamma-T). A linear mixed model showed that, although PSA did not change, the ratio of free PSA:total PSA increased and approached significance (P = 0.07). The alpha-T: gamma-T ratio decreased significantly (P = 0.01), partly reflecting an increase in serum gamma-T, which approached significance (P = 0.08).
Conclusion
The significant decrease in the alpha-T: gamma-T ratio with an increase in serum gamma-T and a trend towards an increase in the ratio of free PSA:total PSA following the 8-week supplement study suggest that walnuts may improve biomarkers of prostate and vascular status.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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