Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis
Hagenau T, Vest R, Gissel TN, Poulsen CS, Erlandsen M, Mosekilde L, Vestergaard P
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 262 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-05-05 · Osteoporos Int · vol. 20 · número 1 · págs. 133–140
- Editorial
- Springer Science+Business Media
- Citado
- 440 citas · más que el 99% de estudios similares · 16.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Skin Protection and Aging · Nutrition and Health Studies
- Palabras clave
- vitamin D status, 25-hydroxyvitamin D, vitamin D deficiency, latitude, skin pigmentation, ethnicity, age differences, sex differences
- MeSH
- humans, vitamin d deficiency, vitamin d, skin pigmentation, incidence, regression analysis, cross-sectional studies, ecology, sunlight, age factors, sex factors, adolescent, adult, aged, middle aged, child, female, male, global health, ethnicity, white people
7 autores
- T. Hagenau🇩🇰Aarhus University Hospital
- R. Vest🇩🇰Aarhus University Hospital
- Tina Gissel🇩🇰Aarhus University Hospital
- Carsten Søndergaard Poulsen🇩🇰Aarhus University Hospital
- Mogens Erlandsen🇩🇰Aarhus University
- Leif Mosekilde🇩🇰Aarhus University Hospital
- Peter Vestergaard🇩🇰 · autor de correspondenciaAarhus University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
We performed a meta-analysis of cross-sectional studies on serum 25(OH)D status globally. Serum 25(OH)D levels on average were 54 nmol/l, were higher in women than men, and higher in Caucasians than in non-Caucasians. There was no trend in serum 25(OH)D level with latitude. Vitamin D deficiency was widespread.
Introduction
We studied vitamin D status (expressed as serum 25-hydroxy-vitamin D [25(OH)D]) in native subjects worldwide.
Methods
Meta-analysis and meta-regression of studies reporting on 25(OH)D in healthy subjects retrieved from Pubmed, Embase and Web of Science using the terms "serum", "25-hydroxy-vitamin D", "cholecalciferol", and "human". A total of 394 studies were included.
Results
The mean 25(OH)D level was 54 nmol/l (95% CI: 52-57 nmol/l). Women had borderline significantly higher 25(OH)D levels than men, and Caucasians had higher levels than non-Caucasians. 25(OH)D levels were higher in subjects aged >15 years than in younger subjects. Unadjusted there was no significant decrease in 25(OH)D with latitude (slope of curve -0.03 +/- 0.12 nmol/l per degree latitude north or south of equator, p = 0.8). There was a significant decline with latitude for Caucasians (-0.69 +/- 0.30 nmol/l per degree, p = 0.02), but not for non-Caucasians (0.03 +/- 0.39 nmol/l per degree, p = 0.14). After adjustment for age, gender, and ethnicity, no overall correlation was present between 25(OH)D and latitude (-0.29 +/- 0.24 nmol/l per degree, p = 0.23).
Conclusion
There was no overall influence of latitude on 25(OH)D. However, in separate analyses 25(OH)D decreased with latitude in Caucasians but not in non-Caucasians. A widespread global vitamin D insufficiency was present compared with proposed threshold levels.
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