A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers
Kaul N, Kreml R, Austria JA, Richard MN, Edel AL, Dibrov E, Hirono S, Zettler ME, Pierce GN
Journal of the American College of Nutrition · 107 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-02-01 · J Am Coll Nutr · vol. 27 · número 1 · págs. 51–58
- Editorial
- Taylor & Francis
- Citado
- 161 citas · más que el 95% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Nutritional Studies and Diet
- Palabras clave
- fish oil, linseed oil, hemp oil, dietary supplementation, cardiovascular health, omega-3 fatty acids, omega-6 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, alpha-linolenic acid, plasma lipid profile, LDL oxidation, platelet aggregation, inflammatory markers, healthy volunteers
- MeSH
- humans, cannabis, cardiovascular diseases, linseed oil, fatty acids, triglycerides, fish oils, plant oils, treatment outcome, risk factors, double-blind method, lipid peroxidation, platelet aggregation, dietary supplements, adult, female, male, lipid metabolism, cholesterol, ldl, cholesterol, hdl
9 autores
- Nalini Kaul🇨🇦St. Boniface Hospital; University of Manitoba
- Renee Kreml🇨🇦St. Boniface Hospital; University of Manitoba
- Jose Alejandro Austria🇨🇦St. Boniface Hospital; University of Manitoba
- Mélanie N. Richard🇨🇦St. Boniface Hospital; University of Manitoba
- Andrea L. Edel🇨🇦St. Boniface Hospital; University of Manitoba
- Elena Dibrov🇨🇦St. Boniface Hospital; University of Manitoba
- Satoru Hirono🇨🇦St. Boniface Hospital; University of Manitoba
- Marjorie E. Zettler🇨🇦St. Boniface Hospital; University of Manitoba
- Grant N. Pierce🇨🇦 · autor de correspondenciaSt. Boniface Hospital; University of Manitoba
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The impact of dietary polyunsaturated fatty acids (PUFAs) of the n-6 and n-3 series on the cardiovascular system is well documented. To directly compare the effects of three dietary oils (fish, flaxseed and hempseed) given in concentrations expected to be self-administered in the general population on specific cardiovascular parameters in healthy volunteers.
Design
86 healthy male and female volunteers completed a 12 week double blinded, placebo controlled, clinical trial. They were randomly assigned to one of the four groups. Subjects were orally supplemented with two 1 gm capsules of placebo, fish oil, flaxseed oil or hempseed oil per day for 12 weeks.
Results
Plasma levels of the n-3 fatty acids docosahexanoic acid and eicosapentanoic acid increased after 3 months supplementation with fish oil. Alpha linolenic acid concentrations increased transiently after flaxseed supplementation. However, supplementation with hempseed oil did not significantly alter the concentration of any plasma fatty acid. The lipid parameters (TC, HDL-C, LDL-C and TG) did not show any significant differences among the four groups. Oxidative modification of LDL showed no increase in lag time over the 12 wk period. None of the dietary interventions induced any significant change in collagen or thrombin stimulated platelet aggregation and no increase in the level of inflammatory markers was observed.
Conclusion
From a consumer's perspective, ingesting 2 capsules of any of these oils in an attempt to achieve cardiovascular health benefits may not provide the desired or expected result over a 3 month period.
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