Financiado en parte por GlaxoSmithKline
High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine
Pedersen DJ, Lessard SJ, Coffey VG, Churchley EG, Wootton AM, Ng T, Watt MJ, Hawley JA
Journal of applied physiology (Bethesda, Md. : 1985) · 54 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- GlaxoSmithKline
Según 1 financiador declarado.
Publicación
- Publicado
- 2008-05-09 · J Appl Physiol (1985) · vol. 105 · número 1 · págs. 7–13
- Editorial
- American Physiological Society
- Citado
- 122 citas · más que el 93% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Coffee research and impacts · Exercise and Physiological Responses
- Palabras clave
- muscle glycogen resynthesis, caffeine, post-exercise recovery, exhaustive exercise, CaMKII phosphorylation, AMPK, Akt signaling, trained cyclists
- MeSH
- muscle, skeletal, humans, caffeine, glycogen, insulin, protein kinases, cyclic amp-dependent protein kinases, dietary carbohydrates, blood glucose, central nervous system stimulants, exercise test, blotting, western, exercise, diet, cross-over studies, double-blind method, signal transduction, anaerobic threshold, kinetics, bicycling, adult, male, oncogene protein v-akt
8 autores
- David J. Pedersen🇦🇺RMIT University
- Sarah J. Lessard
- Vernon G. Coffey
- Emmanuel G. Churchley
- Andrew M. Wootton
- They Ng
- Matthew J. Watt
- John Alan Hawley
Resumen
El texto original del estudio, en el idioma en que se publicó.
We determined the effect of coingestion of caffeine (Caff) with carbohydrate (CHO) on rates of muscle glycogen resynthesis during recovery from exhaustive exercise in seven trained subjects who completed two experimental trials in a randomized, double-blind crossover design. The evening before an experiment subjects performed intermittent exhaustive cycling and then consumed a low-CHO meal. The next morning subjects rode until volitional fatigue. On completion of this ride subjects consumed either CHO [4 g/kg body mass (BM)] or the same amount of CHO + Caff (8 mg/kg BM) during 4 h of passive recovery. Muscle biopsies and blood samples were taken at regular intervals throughout recovery. Muscle glycogen levels were similar at exhaustion [ approximately 75 mmol/kg dry wt (dw)] and increased by a similar amount ( approximately 80%) after 1 h of recovery (133 +/- 37.8 vs. 149 +/- 48 mmol/kg dw for CHO and Caff, respectively). After 4 h of recovery Caff resulted in higher glycogen accumulation (313 +/- 69 vs. 234 +/- 50 mmol/kg dw, P < 0.001). Accordingly, the overall rate of resynthesis for the 4-h recovery period was 66% higher in Caff compared with CHO (57.7 +/- 18.5 vs. 38.0 +/- 7.7 mmol x kg dw(-1) x h(-1), P < 0.05). After 1 h of recovery plasma Caff levels had increased to 31 +/- 11 microM (P < 0.001) and at the end of the recovery reached 77 +/- 11 microM (P < 0.001) with Caff. Phosphorylation of CaMK(Thr286) was similar after exercise and after 1 h of recovery, but after 4 h CaMK(Thr286) phosphorylation was higher in Caff than CHO (P < 0.05). Phosphorylation of AMP-activated protein kinase (AMPK)(Thr172) and Akt(Ser473) was similar for both treatments at all time points. We provide the first evidence that in trained subjects coingestion of large amounts of Caff (8 mg/kg BM) with CHO has an additive effect on rates of postexercise muscle glycogen accumulation compared with consumption of CHO alone.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.