The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation
Johnson EJ, Chung HY, Caldarella SM, Snodderly DM
The American journal of clinical nutrition · 85 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-05-01 · Am J Clin Nutr · vol. 87 · número 5 · págs. 1521–1529
- Editorial
- Elsevier BV
- Citado
- 137 citas · más que el 99% de estudios similares · 12.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Retinal Diseases and Treatments · Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress
- Palabras clave
- lutein supplementation, docosahexaenoic acid, omega-3 fatty acids, macular pigment optical density, macular pigmentation, lipoprotein subfractions
- MeSH
- retina, macula lutea, humans, macular degeneration, lutein, docosahexaenoic acids, lipoproteins, analysis of variance, dietary supplements, aged, aged, 80 and over, middle aged, female
4 autores
- Elizabeth J. Johnson🇺🇸🇰🇷 · autor de correspondenciaTufts University; Yonsei University; Augusta University; Jean Mayer Human Nutrition Research Center on Aging
- Hae-Yun Chung🇺🇸🇰🇷Tufts University; Yonsei University; Augusta University; Jean Mayer Human Nutrition Research Center on Aging
- Susan M. Caldarella🇺🇸🇰🇷Tufts University; Yonsei University; Augusta University; Jean Mayer Human Nutrition Research Center on Aging
- D. Max Snodderly🇺🇸🇰🇷Tufts University; Yonsei University; Augusta University; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Lutein and docosahexaenoic acid (DHA) may protect against age-related macular degeneration (AMD). Lutein is a component of macular pigment. DHA is in the retina.
Objective
The objective of this 4-mo study was to determine the effects of lutein (12 mg/d) and DHA (800 mg/d) on their serum concentrations and macular pigment optical density (MPOD).
Design
Forty-nine women (60-80 y) were randomly assigned to placebo, DHA, lutein, or lutein + DHA supplement. Serum was analyzed for lutein and DHA (0, 2, and 4 mo). MPOD was determined (0 and 4 mo) at 0.4, 1.5, 3, and 5 degrees temporal retinal eccentricities. Serum was analyzed for lipoproteins (4 mo).
Results
There was no interaction between lutein and DHA supplementations for serum lutein and MPOD. The lutein supplementation x DHA supplementation x month interaction was significant for serum DHA response (P < 0.05). In the lutein group, serum lutein increased from baseline at 2 and 4 mo (P < 0.001), and MPOD increased at 3.0 degrees (P < 0.01). In the DHA group, serum DHA increased at 2 and 4 mo (P < 0.0001), and MPOD increased at 0.4 degrees (P < 0.05). In the lutein + DHA group, serum lutein and DHA increased at 2 and 4 mo (P < 0.01), and MPOD increased at 0.4, 1.5, and 3 degrees (P = 0.06, 0.08, and 0.09, respectively). Differences from placebo in lipoprotein subfractions were greatest for the lutein + DHA group (4 mo).
Conclusions
Lutein supplementation increased MPOD eccentrically. DHA resulted in central increases. These results may be due to changes in lipoproteins. Lutein and DHA may aid in prevention of age-related macular degeneration.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.