Omega-3 fatty acids effect on wound healing
McDaniel JC, Belury M, Ahijevych K, Blakely W
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 109 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Nursing Research
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NINR NIH HHS
- Subvenciones
- National Institute of Nursing Research (F31 NR009134); National Center for Research Resources (UL1RR025755); National Institute of Nursing Research (1 F31 NR009134-01)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2008-05-01 · Wound Repair Regen · vol. 16 · número 3 · págs. 337–345
- Editorial
- Wiley
- Citado
- 164 citas · más que el 94% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Wound Healing and Treatments · Seaweed-derived Bioactive Compounds
- Palabras clave
- omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, polyunsaturated fatty acids, skin wound healing, inflammatory cytokines, IL-1β, interleukin-6, TNF-α, blister fluid, plasma fatty acids, dietary supplementation, wound closure time
- MeSH
- humans, blister, docosahexaenoic acids, eicosapentaenoic acid, tumor necrosis factor-alpha, double-blind method, wound healing, adult, female, male, interleukin-1beta, interleukin-1alpha
4 autores
- Jodi Christine McDaniel🇺🇸The Ohio State University
- Martha Ann Belury🇺🇸The Ohio State University
- Karen Ahijevych🇺🇸The Ohio State University
- W. Paul Blakely🇺🇸The Ohio State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Physiological events in the initial inflammatory stage of cutaneous wound healing influence subsequent stages. Proinflammatory cytokines coordinate molecular and cellular processes during the inflammatory stage. Polyunsaturated fatty acids (PUFA) alter proinflammatory cytokine production, but how this phenomenon specifically influences wound healing is not clearly understood. In the present study, effects of marine-derived omega-3 eicosapentaenoic and docosahexaenoic PUFA on proinflammatory cytokines in wound serum and time to complete healing in healthy, human skin were evaluated. We compared plasma fatty acid levels in two groups (N=30) at baseline and after 4 weeks of eicosapentaenoic/docosahexaenoic PUFA supplements (active) or placebo (control). Eight small blisters on participants' forearms were created. Proinflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha were quantified in blister fluid at 5 and 24 hours after creation. Wound area was calculated daily. Eicosapentaenoic and docosahexaenoic plasma fatty acid levels were significantly higher in the active group. Additionally, we found significantly higher IL-1beta levels in blister fluid in the active group and time to complete wound closure was somewhat longer. These results suggest that eicosapentaenoic and docosahexaenoic PUFA may increase proinflammatory cytokine production at wound sites and thus, depending on the clinical context, have noninvasive, therapeutic potential to affect cutaneous wound healing.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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