Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly
Romagnoli E, Mascia ML, Cipriani C, Fassino V, Mazzei F, D'Erasmo E, Carnevale V, Scillitani A, Minisola S
The Journal of clinical endocrinology and metabolism · 231 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-05-20 · J Clin Endocrinol Metab · vol. 93 · número 8 · págs. 3015–3020
- Editorial
- Oxford University Press
- Citado
- 331 citas · más que el 99% de estudios similares · 16.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Bone health and osteoporosis research
- Palabras clave
- vitamin D2, vitamin D3, high-dose vitamin D supplementation, vitamin D deficiency, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, ionized calcium, older adults, nursing home residents, oral versus intramuscular administration, bioavailability
- MeSH
- humans, calcium, cholecalciferol, calcitriol, ergocalciferols, parathyroid hormone, vitamin d, prospective studies, aged, aged, 80 and over, female
9 autores
- Elisabetta Romagnoli🇮🇹 · autor de correspondenciaSapienza University of Rome
- Maria Lucia Mascia🇮🇹Sapienza University of Rome
- Cristiana Cipriani🇮🇹Sapienza University of Rome
- Valeria Fassino🇮🇹Sapienza University of Rome
- Franco Mazzei🇮🇹Sapienza University of Rome
- Emilio D'Erasmo🇮🇹Sapienza University of Rome
- Vincenzo Carnevale🇮🇹Casa Sollievo della Sofferenza
- Alfredo Scillitani🇮🇹Casa Sollievo della Sofferenza
- Salvatore Minisola🇮🇹Sapienza University of Rome
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
In humans, few studies have compared the potencies of ergocalciferol and cholecalciferol in improving and maintaining vitamin D status.
Objective
Our objective was to evaluate the effects of a single very large dose of both calciferols on serum changes of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)(2)D], ionized calcium, and parathyroid hormone (PTH) at baseline, and at 3, 7, 30, and 60 d.
Design
This was a prospective randomized intervention study.
Setting
The study was performed in a nursing home residence.
Participants
A total of 32 elderly female patients (age range 66-97 yr), with vitamin D deficiency was included in the study.
Intervention
Participants were randomized into four groups of eight to receive a single dose of 300,000 IU ergocalciferol or cholecalciferol by oral (os) or im route.
Results
25(OH)D levels sharply increased at d 3 only when vitamins were given os. The 30-d basal difference in serum 25(OH)D was significantly greater after cholecalciferol os administration (47.8 +/- 7.3 ng/ml) compared with other forms (D(3) im: 15.9 +/- 11.3; D(2) os: 17.3 +/- 4.7; D(2) im: 5 +/- 4.4; all P < 0.001). The area under the curve (AUC) of the serum 25(OH)D against time (AUC(60)) was: D(3) os, 3193 +/- 759 ng x d/ml vs. D(2) os, 1820 +/- 512, P < 0.001; and D(3) im, 1361 +/- 492 vs. D(2) im, 728 +/- 195, P < 0.01. 25(OH)D significantly influences PTH levels at 3 (P < 0.03), 7 (P < 0.01), 30 (P < 0.01), and 60 d (P < 0.05). At 60 d, the form of vitamin (cholecalciferol) significantly lowers PTH levels (P = 0.037).
Conclusions
Cholecalciferol is almost twice as potent as ergocalciferol in increasing serum 25(OH)D, when administered either by mouth or im. 25(OH)D plays a role in modulating serum PTH.
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