Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women
Johnson EJ, McDonald K, Caldarella SM, Chung HY, Troen AM, Snodderly DM
Nutritional neuroscience · 198 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- Food and Nutrition Service
Según 2 financiadores declarados.
Publicación
- Publicado
- 2008-04-01 · Nutr Neurosci · vol. 11 · número 2 · págs. 75–83
- Editorial
- Taylor & Francis
- Citado
- 291 citas · más que el 96% de estudios similares · 6.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- docosahexaenoic acid, lutein, omega-3 supplementation, cognitive function, older women, cognitive decline, verbal fluency, memory, learning, processing speed, mood, dietary supplementation
- MeSH
- humans, lutein, docosahexaenoic acids, placebos, double-blind method, speech, affect, cognition, learning, memory, cognition disorders, dietary supplements, aged, aged, 80 and over, middle aged, female
6 autores
- Elizabeth J. Johnson🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Karen Q. McDonald🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Susan M. Caldarella🇺🇸Tufts University; Harvard University; Jean Mayer Human Nutrition Research Center on Aging
- Hae-Yun Chung🇺🇸🇰🇷Tufts University; Yonsei University; Jean Mayer Human Nutrition Research Center on Aging
- Aron M. Troen🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- D. Max Snodderly🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Low dietary intake of docosahexaenoic acid (DHA) and/or foods rich in lutein may be associated with increased risk of cognitive decline in the elderly.
Subjects and methods
The cognitive benefit of DHA and lutein in unimpaired elder women was explored in the context of a 4-month, double-blind, intervention trial of DHA and lutein supplementation for eye health. Forty-nine women (aged 60-80 years) were randomized to receive DHA (800 mg/day; n = 14), lutein (12 mg/day; n = 11), a combination of DHA and lutein (n = 14) or placebo (n = 10). Subjects underwent cognitive tests measuring verbal fluency, memory, processing speed and accuracy, and self-reports of mood at randomization and upon completion of the trial.
Results
Following supplementation, verbal fluency scores improved significantly in the DHA, lutein, and combined treatment groups (P < 0.03). Memory scores and rate of learning improved significantly in the combined treatment group (P < 0.03), who also displayed a trend toward more efficient learning (P = 0.07). Measures of mental processing speed, accuracy and mood were not affected by supplementation.
Conclusions
These exploratory findings suggest that DHA and lutein supplementation may have cognitive benefit for older adults.
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