Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid
Henriksen C, Haugholt K, Lindgren M, Aurvåg AK, Rønnestad A, Grønn M, Solberg R, Moen A, Nakstad B, Berge RK, Smith L, Iversen PO, Drevon CA
Pediatrics · 169 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- EkstraStiftelsen Helse og Rehabilitering (Stiftelsen Dam)
- Organización sin fines de lucro
- Direktør Throne Holsts Fond For Ernæringsforskning
Según 2 financiadores declarados.
Publicación
- Publicado
- 2008-06-01 · Pediatrics · vol. 121 · número 6 · págs. 1137–1145
- Editorial
- American Academy of Pediatrics
- Citado
- 238 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Infant Development and Preterm Care
- Palabras clave
- preterm infants, docosahexaenoic acid, arachidonic acid, cognitive development, recognition memory, event-related potentials, problem solving, very low birth weight infants, neonatal nutrition
- MeSH
- humans, docosahexaenoic acids, arachidonic acid, double-blind method, child development, cognition, age factors, breast feeding, dietary supplements, infant, newborn, infant, very low birth weight, infant, premature, female, male
13 autores
- Christine HenriksenInstitute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
- Kristin Haugholt🇳🇴University of Oslo
- Magnus P. Lindgren🇳🇴🇸🇪University of Oslo; Lund University
- Anne Karin Aurvåg🇳🇴University of Oslo; Akershus University Hospital
- Arild Erlend Rønnestad
- Morten Grønn
- Rønnaug Solberg🇳🇴Sykehuset i Vestfold
- Atle Møen
- Britt Nakstad🇳🇴University of Oslo; Akershus University Hospital
- Rolf Kristian Berge🇳🇴University of Bergen
- Lars Smith🇳🇴University of Oslo
- Per Ole IversenInstitute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
- Christian Andre DrevonInstitute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The objective of our study was to evaluate the effect of supplementation with docosahexaenoic acid and arachidonic acid for human milk-fed preterm infants. The primary end point was cognitive development at 6 months of age.
Methods
The study was a randomized, double-blind, placebo-controlled study among 141 infants with birth weights of <1500 g. The intervention with 32 mg of docosahexaenoic acid and 31 mg of arachidonic acid per 100 mL of human milk started 1 week after birth and lasted until discharge from the hospital (on average, 9 weeks). Cognitive development was evaluated at 6 months of age by using the Ages and Stages Questionnaire and event-related potentials, a measure of brain correlates related to recognition memory.
Results
There was no difference in adverse events or growth between the 2 groups. At the 6-month follow-up evaluation, the intervention group performed better on the problem-solving subscore, compared with the control group (53.4 vs 49.5 points). There was also a nonsignificant higher total score (221 vs 215 points). The event-related potential data revealed that infants in the intervention group had significantly lower responses after the standard image, compared with the control group (8.6 vs 13.2). There was no difference in responses to novel images.
Conclusions
Supplementation with docosahexaenoic acid and arachidonic acid for very preterm infants fed human milk in the early neonatal period was associated with better recognition memory and higher problem-solving scores at 6 months.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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