Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study
Vedin I, Cederholm T, Freund Levi Y, Basun H, Garlind A, Faxén Irving G, Jönhagen ME, Vessby B, Wahlund LO, Palmblad J
The American journal of clinical nutrition · 116 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-06-01 · Am J Clin Nutr · vol. 87 · número 6 · págs. 1616–1622
- Editorial
- Elsevier BV
- Citado
- 171 citas · más que el 99% de estudios similares · 11.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- docosahexaenoic acid, omega-3 supplementation, fish oil, Alzheimer's disease, peripheral blood mononuclear cells, cytokine production, interleukin-6, IL-1β, granulocyte colony-stimulating factor, eicosapentaenoic acid, lipopolysaccharide stimulation, anti-inflammatory activity, plasma fatty acid concentrations
- MeSH
- leukocytes, mononuclear, humans, alzheimer disease, inflammation, lipopolysaccharides, fatty acids, omega-3, docosahexaenoic acids, fish oils, growth substances, granulocyte colony-stimulating factor, interleukin-6, cytokines, leukocyte count, lymphocyte count, double-blind method, dietary supplements, aged, female, male, interleukin-1beta
10 autores
- Inger Vedin🇸🇪Uppsala University Hospital
- Tommy Cederholm
- Yvonne Freund‐Levi
- Hans Basun
- Anita Garlind
- Gerd Faxén Irving
- Maria Eriksdotter Jönhagen
- Bengt OH Vessby
- Lars‐Olof Wahlund
- Jan E.W. Palmblad · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary fish or fish oil rich in n-3 fatty acids (n-3 FAs), eg, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), ameliorate inflammatory reactions by various mechanisms. Whereas most studies have explored the effects of predominantly EPA-based n-3 FAs preparations, few have addressed the effects of n-3 FAs preparations with DHA as the main FA.
Objective
The objective was to determine the effects of 6 mo of dietary supplementation with an n-3 FAs preparation rich in DHA on release of cytokines and growth factors from peripheral blood mononuclear cells (PBMCs).
Design
In a randomized, double-blind, placebo-controlled trial, 174 Alzheimer disease (AD) patients received daily either 1.7 g DHA and 0.6 g EPA (n-3 FAs group) or placebo for 6 mo. In the present study blood samples were obtained from the 23 first randomized patients, and PBMCs were isolated before and after 6 mo of treatment.
Results
Plasma concentrations of DHA and EPA were significantly increased at 6 mo in the n-3 FAs group. This group also showed significant decreases of interleukin (IL)-6, IL-1beta, and granulocyte colony-stimulating factor secretion after stimulation of PBMCs with lipopolysaccharide. Changes in the DHA and EPA concentrations were negatively associated with changes in IL-1beta and IL-6 release for all subjects. Reductions of IL-1beta and IL-6 were also significantly correlated with each other. In contrast, this n-3 FA treatment for 6 mo did not decrease tumor necrosis factor-alpha, IotaL-8, IL-10, and granulocyte-macrophage colony-stimulating factor secretion.
Conclusion
AD patients treated with DHA-rich n-3 FAs supplementation increased their plasma concentrations of DHA (and EPA), which were associated with reduced release of IL-1beta, IL-6, and granulocyte colony-stimulating factor from PBMCs. This trial was registered at clinicaltrials.gov as NCT00211159.
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