Magnesium supplementation helps to improve carotid intima media thickness in patients on hemodialysis
Turgut F, Kanbay M, Metin MR, Uz E, Akcay A, Covic A
International urology and nephrology · 110 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-06-20 · Int Urol Nephrol · vol. 40 · número 4 · págs. 1075–1082
- Editorial
- Springer Science+Business Media
- Citado
- 167 citas · más que el 94% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Dialysis and Renal Disease Management
- Palabras clave
- magnesium supplementation, magnesium citrate, carotid intima-media thickness, hemodialysis, atherosclerosis, parathyroid hormone, calcium-phosphate product, phosphate binders, calcium acetate, serum magnesium
- MeSH
- tunica media, carotid arteries, tunica intima, humans, kidney failure, chronic, calcium, phosphorus, citric acid, organometallic compounds, ultrasonography, treatment outcome, renal dialysis, statistics, nonparametric, adult, middle aged, female, male
6 autores
- Faruk Hilmi Turgut🇹🇷 · autor de correspondenciaFatih University
- Mehmet Kanbay🇹🇷Fatih University
- Melike Ruşen Metin🇹🇷Fatih University
- Ebru Uz🇹🇷Fatih University
- Ali Akçay🇹🇷Fatih University
- Adrian Constantin Covic🇷🇴Spitalul Clinic Dr. C. I. Parhon
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The atherosclerotic process progresses more dynamically in hemodialysis (HD) patients than in the general population. In HD patients, lower magnesium levels were reported to be associated with increased atherosclerosis of the common carotid artery. We tested the hypotheses that magnesium supplementation helps to improve carotid intima media thickness (IMT) in HD patients.
Materials and methods
A total of 47 patients on HD were included in the study. Patients were randomly divided into two groups: group A (Mg group), in which patients were given magnesium citrate orally at a dosage of 610 mg every other day for 2 months and group B (control group), in which patients received only calcium acetate therapy as a phosphate binder. At baseline and 2 months later, all patients underwent a carotid artery ultrasound scan to measure carotid IMT.
Results
At the end of 2 months, mean serum calcium, phosphorus, and calcium x phosphorus product were not changed in both groups. As expected, mean serum Mg level significantly increased in the Mg group at the end of 2 months. In addition, serum parathyroid hormone (PTH) level significantly decreased in the Mg group at the end of 2 months (P = 0.003). Baseline carotid IMT was similar between the groups. Bilateral carotid IMT was significantly improved in patients treated with magnesium citrate compared to initial values (P = 0.001 for left, P = 0.002 for right).
Conclusion
Based on the present data, magnesium may play an important protective role in the progression of atherosclerosis in patients on dialysis. Further studies are needed to assess more accurately the role of magnesium in atherosclerotic regression in dialysis patients.
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