Immunologic properties differ in preterm infants fed olive oil vs soy-based lipid emulsions during parenteral nutrition
Gawecka A, Michalkiewicz J, Kornacka MK, Luckiewicz B, Kubiszewska I
JPEN. Journal of parenteral and enteral nutrition · 25 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-07-01 · JPEN J Parenter Enteral Nutr · vol. 32 · número 4 · págs. 448–453
- Editorial
- Wiley
- Citado
- 55 citas · más que el 93% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Infant Nutrition and Health · Fatty Acid Research and Health
- Palabras clave
- preterm infants, parenteral nutrition, lipid emulsions, olive oil, soybean oil, cytokine production, interleukin-6, TNF-α, IL-10, peripheral blood mononuclear cells, anti-CD3 stimulation, T cell activation, neonatal immune response
- MeSH
- leukocytes, mononuclear, humans, soybean oil, fat emulsions, intravenous, plant oils, tumor necrosis factor-alpha, interleukin-6, interleukin-10, treatment outcome, parenteral nutrition, double-blind method, infant, newborn, infant, premature, female, male, infant nutritional physiological phenomena, olive oil
5 autores
- Agnieszka Gawecka🇵🇱 · autor de correspondenciaMedical University of Warsaw
- Jacek Michałkiewicz🇵🇱Children's Memorial Health Institute
- Maria Katarzyna Borszewska-Kornacka🇵🇱Medical University of Warsaw
- Barbara Łuckiewicz
- Izabela Kubiszewska🇵🇱Collegium Medicum in Bydgoszcz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
In the first period of life, premature infants need parenteral nutrition. Lipid emulsions (LEs), which are a part of parenteral nutrition, are known as potent immunological modulators and may therefore influence the immune status of parenterally fed infants. The aim of the study was to compare tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-10 production in the peripheral blood mononuclear cells (PBMCs) of premature infants parenterally fed with 2 LEs: olive oil (OO) and soybean oil (SO).
Methods
Premature infants born at <32 weeks' gestation and with a birth weight <1500 g were randomized in a double-blind method within the first 48 hours of life to receive 1 of 2 LEs: OO based or SO based. At baseline and after 14 days, blood samples were collected, and PBMCs were isolated and then cultured for 48 hours in medium only and in the presence of anti-CD3 antibodies.
Results
Of 44 recruited infants, 38 completed the study, 18 in the OO group and 20 in the SO group. The cytokine synthesis profile before the LE introduction was the same in both groups (nonstimulated and anti-CD3-induced PBMC). In the succeeding 14 days of parenteral nutrition, TNF-alpha, IL-6, and IL-10 levels in nonstimulated PBMCs remained unchanged in both groups. In contrast, IL-6 production was significantly higher in the SO group.
Conclusions
SO-based LE may promote an excess of IL-6 production, especially in the T cell-dependent way of PBMC activation (via anti-CD3). OO emulsion seems to be immunologically more neutral than SO emulsion.
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