Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial
Olsen SF, Østerdal ML, Salvig JD, Mortensen LM, Rytter D, Secher NJ, Henriksen TB
The American journal of clinical nutrition · 139 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-07-01 · Am J Clin Nutr · vol. 88 · número 1 · págs. 167–175
- Editorial
- Elsevier BV
- Citado
- 235 citas · más que el 100% de estudios similares · 18.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Asthma and respiratory diseases · Birth, Development, and Health
- Palabras clave
- fish oil, olive oil, omega-3 fatty acids, maternal supplementation, late pregnancy, asthma, allergic asthma, intrauterine environment, immunomodulation
- MeSH
- humans, asthma, prenatal exposure delayed effects, fatty acids, omega-3, fish oils, plant oils, registries, follow-up studies, pregnancy, dietary supplements, adolescent, adult, female, male, maternal nutritional physiological phenomena, olive oil
7 autores
- Sjurdur Frodi Olsen🇩🇰🇺🇸 · autor de correspondenciaStatens Serum Institut; University of Copenhagen; Harvard University; Aarhus University; Aarhus University Hospital
- Marie Louise Østerdal🇩🇰🇺🇸Statens Serum Institut; University of Copenhagen; Harvard University; Aarhus University; Aarhus University Hospital
- Jannie Dalby Salvig🇩🇰🇺🇸Statens Serum Institut; University of Copenhagen; Harvard University; Aarhus University; Aarhus University Hospital
- Lotte Maxild Mortensen🇩🇰🇺🇸Statens Serum Institut; University of Copenhagen; Harvard University; Aarhus University; Aarhus University Hospital
- Dorte Rytter🇩🇰🇺🇸Statens Serum Institut; University of Copenhagen; Harvard University; Aarhus University; Aarhus University Hospital
- Niels Jørgen Secher🇩🇰🇺🇸Statens Serum Institut; University of Copenhagen; Harvard University; Aarhus University; Aarhus University Hospital
- Tine Brink Henriksen🇩🇰🇺🇸Statens Serum Institut; University of Copenhagen; Harvard University; Aarhus University; Aarhus University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Evidence suggests that asthma is rooted in the intrauterine environment and that intake of marine n-3 polyunsaturated fatty acids (n-3 PUFAs) in pregnancy may have immunomodulatory effects on the child.
Objective
Our aim was to examine whether increasing maternal intake of n-3 PUFAs in pregnancy may affect offspring risk of asthma.
Design
In 1990, a population-based sample of 533 women with normal pregnancies were randomly assigned 2:1:1 to receive four 1-g gelatin capsules/d with fish oil providing 2.7 g n-3 PUFAs (n = 266); four 1-g, similar-looking capsules/d with olive oil (n = 136); or no oil capsules (n = 131). Women were recruited and randomly assigned around gestation week 30 and asked to take capsules until delivery. Among 531 live-born children, 528 were identified in registries and 523 were still alive by August 2006. Diagnoses from the International Coding of Diseases version 10 were extracted from a mandatory registry that recorded diagnoses reported from hospital contacts.
Results
During the 16 y that passed since childbirth, 19 children from the fish oil and olive oil groups had received an asthma-related diagnosis; 10 had received the diagnosis allergic asthma. The hazard rate of asthma was reduced by 63% (95% CI: 8%, 85%; P = 0.03), whereas the hazard rate of allergic asthma was reduced by 87% (95% CI: 40%, 97%; P = 0.01) in the fish oil compared with the olive oil group.
Conclusion
Under the assumption that intake of olive oil in the dose provided here was inert, our results support that increasing n-3 PUFAs in late pregnancy may carry an important prophylactic potential in relation to offspring asthma.
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