Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial
Webb AN, Hardy P, Peterkin M, Lee O, Shalley H, Croft KD, Mori TA, Heine RG, Bines JE
Nutrition (Burbank, Los Angeles County, Calif.) · 37 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-07-11 · Nutrition · vol. 24 · número 11-12 · págs. 1057–1064
- Editorial
- Elsevier BV
- Citado
- 62 citas · más que el 91% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Infant Nutrition and Health · Fatty Acid Research and Health
- Palabras clave
- parenteral nutrition, critically ill neonates, oleic acid, linoleic acid, plasma phospholipid fatty acids, F2-isoprostanes, liver function, safety and tolerability, ClinOleic, Intralipid
- MeSH
- liver, humans, critical illness, soybean oil, fat emulsions, intravenous, fatty acids, f2-isoprostanes, linoleic acid, oleic acid, phospholipids, plant oils, treatment outcome, parenteral nutrition, double-blind method, infant, newborn, female, male, infant nutritional physiological phenomena, olive oil
9 autores
- Annette Webb🇦🇺Royal Children's Hospital; Murdoch Children's Research Institute
- Pollyanna Hardy🇦🇺Royal Children's Hospital; Murdoch Children's Research Institute
- Megan Peterkin🇦🇺Royal Children's Hospital
- Olive Lee🇦🇺Murdoch Children's Research Institute
- Helen Shalley🇦🇺Royal Children's Hospital
- Kevin D. Croft🇦🇺The University of Western Australia
- Trevor Anthony Mori🇦🇺The University of Western Australia
- Ralf G. Heine🇦🇺Royal Children's Hospital; The University of Melbourne; Murdoch Children's Research Institute
- Julie E. Bines🇦🇺 · autor de correspondenciaRoyal Children's Hospital; The University of Melbourne; Murdoch Children's Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We assessed the safety and tolerability of an olive oil-based lipid emulsion compared with a soybean-based lipid emulsion in critically ill neonates.
Methods
A double-blinded, randomized study was conducted in critically ill neonates requiring parenteral nutrition in the first week of life. Infants were randomized to receive a lipid emulsion based on olive oil (OO; ClinOleic) or soybean oil (SO; Intralipid) for a minimum of 5 d. Plasma phospholipid fatty acids, F(2)-isoprostanes, liver function, and clinical outcome were assessed after 5 d of therapy.
Results
Seventy-eight neonates (men gestational age 37 wk, range 26-41 wk) received OO (n = 39) or SO (n = 39). Both emulsions were well tolerated with no adverse events observed. At day 5, plasma phospholipid oleic acid (C18:1omega-9) levels increased in infants receiving OO compared with lower levels in infants receiving SO (mean percentage +/- SD 33.1 +/- 6.4 for OO versus 18.6 +/- 2.4 for SO; mean difference -14.7 mmol/L, 95% confidence interval -17.5 to -11.9). The increase in plasma phospholipid linoleic acid levels was attenuated in infants receiving OO (mean percentage +/- SD 12.6 +/- 3.0 for OO versus 23.7 +/- 6.9 for SO; adjusted mean 11.4 mmol/L, 95% confidence interval 8.1-14.8). No differences were observed in plasma F(2)-isoprostane levels according to the type of lipid emulsion received.
Conclusion
The OO-based emulsion (ClinOleic) was well tolerated in critically ill neonates. Differences in plasma phospholipids at day 5 reflected the fatty acid composition of the administered emulsion. No significant differences in plasma F(2)-isoprostane levels were detected after 5 d of lipid administration.
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