Effect of fish oil on cognitive performance in older subjects: a randomized, controlled trial
van de Rest O, Geleijnse JM, Kok FJ, van Staveren WA, Dullemeijer C, Olderikkert MG, Beekman AT, de Groot CP
Neurology · 253 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-08-04 · Neurology · vol. 71 · número 6 · págs. 430–438
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 382 citas · más que el 100% de estudios similares · 27.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Dementia and Cognitive Impairment Research · Nutritional Studies and Diet
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, cognitive performance, older adults, age-related cognitive decline, attention, memory, executive function, plasma fatty acid concentrations
- MeSH
- humans, eicosapentaenoic acid, fatty acids, unsaturated, fish oils, capsules, double-blind method, cognition, cognition disorders, dietary supplements, aged, female, male
8 autores
- Ondine van de Rest🇳🇱Radboud University Nijmegen; TiFN; Vrije Universiteit Amsterdam
- Johanna Marianne Geleijnse🇳🇱Radboud University Nijmegen; TiFN; Vrije Universiteit Amsterdam
- F.J. Kok🇳🇱Radboud University Nijmegen; TiFN; Vrije Universiteit Amsterdam
- Wija A. van Staveren🇳🇱Radboud University Nijmegen; TiFN; Vrije Universiteit Amsterdam
- Carla Dullemeijer🇳🇱Radboud University Nijmegen; TiFN; Vrije Universiteit Amsterdam
- Marcel G.M. Olde-Rikkert🇳🇱Radboud University Nijmegen; TiFN; Vrije Universiteit Amsterdam
- Aartjan T.F. Beekman🇳🇱Radboud University Nijmegen; TiFN; Vrije Universiteit Amsterdam
- C.P.G.M. de Groot🇳🇱Radboud University Nijmegen; TiFN; Vrije Universiteit Amsterdam
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
High intake of n-3 polyunsaturated fatty acids may protect against age-related cognitive decline. However, results from epidemiologic studies are inconclusive, and results from randomized trials in elderly subjects without dementia are lacking.
Objective
To investigate the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation on cognitive performance.
Methods
Double-blind, placebo-controlled trial involving 302 cognitively healthy (Mini-Mental State Examination score > 21) individuals aged 65 years or older. Participants were randomly assigned to 1,800 mg/d EPA-DHA, 400 mg/d EPA-DHA, or placebo capsules for 26 weeks. Cognitive performance was assessed using an extensive neuropsychological test battery that included the cognitive domains of attention, sensorimotor speed, memory, and executive function.
Results
The mean age of the participants was 70 years, and 55% were male. Plasma concentrations of EPA-DHA increased by 238% in the high-dose and 51% in the low-dose fish oil group compared with placebo, reflecting excellent compliance. Baseline scores on the cognitive tests were comparable in the three groups. Overall, there were no significant differential changes in any of the cognitive domains for either low-dose or high-dose fish oil supplementation compared with placebo.
Conclusions
In this randomized, double-blind, placebo-controlled trial, we observed no overall effect of 26 weeks of eicosapentaenoic acid and docosahexaenoic acid supplementation on cognitive performance.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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