Low-dose creatine combined with protein during resistance training in older men
Candow DG, Little JP, Chilibeck PD, Abeysekara S, Zello GA, Kazachkov M, Cornish SM, Yu PH
Medicine and science in sports and exercise · 112 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-08-14 · Med Sci Sports Exerc · vol. 40 · número 9 · págs. 1645–1652
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 169 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Muscle Physiology and Disorders
- Palabras clave
- creatine supplementation, protein supplementation, resistance training, older men, lean body mass, muscle thickness, strength, formaldehyde, cytotoxicity, myofibrillar protein degradation, 3-methylhistidine, bone resorption, N-terminal telopeptide of type I collagen
- MeSH
- myofibrils, humans, bone resorption, formaldehyde, creatine, dietary proteins, placebos, double-blind method, dose-response relationship, drug, dietary supplements, aged, middle aged, male, muscle strength, resistance training
8 autores
- Darren Glenn Candow🇨🇦University of Regina
- Jonathan P. Little🇨🇦University of Saskatchewan
- Philip David Chilibeck🇨🇦University of Saskatchewan
- Saman Abeysekara
- Gordon Alexander Zello
- Michael Kazachkov🇨🇦University of Saskatchewan
- Stephen M. Cornish🇨🇦University of Saskatchewan
- Peter H. Yu🇨🇦University of Saskatchewan
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To determine whether low-dose creatine and protein supplementation during resistance training (RT; 3 d x wk(-1); 10 wk) in older men (59-77 yr) is effective for improving strength and muscle mass without producing potentially cytotoxic metabolites (formaldehyde).
Methods
Older men were randomized (double-blind) to receive 0.1 g x kg(-1) creatine + 0.3 g x kg(-1) protein (CP; n = 10), creatine (C; n = 13), or placebo (PLA; n = 12) on training days. Measurements before and after RT included lean tissue mass (air-displacement plethysmography), muscle thickness (ultrasound) of elbow, knee, and ankle flexors and extensors, leg and bench press strength, and urinary indicators of cytotoxicity (formaldehyde), myofibrillar protein degradation [3-methylhistidine (3-MH)],and bone resorption [cross-linked N-telopeptides of type I collagen (NTx)].
Results
Subjects in C and CP groups combined experienced greater increases in body mass and total muscle thickness than PLA (P < 0.05). Subjects who received CP increased lean tissue mass (+5.6%) more than C (+2.2%) or PLA (+1.0%; P < 0.05) and increased bench press strength (+25%) to a greater extent than C and PLA combined (+12.5%; P < 0.05). CP and C did not differ from PLA for changes in formaldehyde production (+24% each). Subjects receiving creatine (C and CP) experienced a decrease in 3-MH by 40% compared with an increase of 29% for PLA (P < 0.05) and a reduction in NTx (-27%) versus PLA (+13%; P = 0.05).
Conclusions
Low-dose creatine combined with protein supplementation increases lean tissue mass and results in a greater relative increase in bench press but not leg press strength. Low-dose creatine reduces muscle protein degradation and bone resorption without increasing formaldehyde production.
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