Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults
Burke DG, Candow DG, Chilibeck PD, MacNeil LG, Roy BD, Tarnopolsky MA, Ziegenfuss T
International journal of sport nutrition and exercise metabolism · 52 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-08-01 · Int J Sport Nutr Exerc Metab · vol. 18 · número 4 · págs. 389–398
- Editorial
- Human Kinetics
- Citado
- 105 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Growth Hormone and Insulin-like Growth Factors · Muscle Physiology and Disorders
- Palabras clave
- creatine supplementation, resistance training, insulin-like growth factor I, vastus lateralis, vegetarian diet, sex differences, young adults, muscle hypertrophy
- MeSH
- muscle, skeletal, humans, creatine, insulin-like growth factor i, immunohistochemistry, diet, vegetarian, weight lifting, dietary supplements, adult, female, male
7 autores
- Darren G. Burke🇨🇦St. Francis Xavier University
- Darren Glenn Candow
- Philip David Chilibeck
- Lauren MacNeil
- Brian D. Roy
- Mark Andrew Tarnopolsky
- Tim N. Ziegenfuss
Resumen
El texto original del estudio, en el idioma en que se publicó.
The purpose of this study was to compare changes in muscle insulin-like growth factor-I (IGF-I) content resulting from resistance-exercise training (RET) and creatine supplementation (CR). Male (n=24) and female (n=18) participants with minimal resistance-exercise-training experience (=1 year) who were participating in at least 30 min of structured physical activity (i.e., walking, jogging, cycling) 3-5 x/wk volunteered for the study. Participants were randomly assigned in blocks (gender) to supplement with creatine (CR: 0.25 g/kg lean-tissue mass for 7 days; 0.06 g/kg lean-tissue mass for 49 days; n=22, 12 males, 10 female) or isocaloric placebo (PL: n=20, 12 male, 8 female) and engage in a whole-body RET program for 8 wk. Eighteen participants were classified as vegetarian (lacto-ovo or vegan; CR: 5 male, 5 female; PL: 3 male, 5 female). Muscle biopsies (vastus lateralis) were taken before and after the intervention and analyzed for IGF-I using standard immunohistochemical procedures. Stained muscle cross-sections were examined microscopically and IGF-I content quantified using image-analysis software. Results showed that RET increased intramuscular IGF-I content by 67%, with greater accumulation from CR (+78%) than PL (+54%; p=.06). There were no differences in IGF-I between vegetarians and nonvegetarians. These findings indicate that creatine supplementation during resistance-exercise training increases intramuscular IGF-I concentration in healthy men and women, independent of habitual dietary routine.
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