Low-level laser therapy in the prevention and treatment of chemotherapy-induced oral mucositis in young patients
Abramoff MM, Lopes NN, Lopes LA, Dib LL, Guilherme A, Caran EM, Barreto AD, Lee ML, Petrilli AS
Photomedicine and laser surgery · 68 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-08-01 · Photomed Laser Surg · vol. 26 · número 4 · págs. 393–400
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 111 citas · más que el 96% de estudios similares · 6.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, chemotherapy-induced mucositis, mucositis prevention, young cancer patients, granulocytopenia, analgesia, anti-inflammatory activity
- MeSH
- mouth mucosa, granulocytes, humans, stomatitis, antineoplastic combined chemotherapy protocols, leukocyte count, treatment outcome, prospective studies, feasibility studies, pilot projects, adolescent, child, female, male, young adult, low-level light therapy
9 autores
- Meire Maman Fracher Abramoff
- Nilza Nelly Fontana Lopes🇧🇷Support group for adolescents and children with cancer; Universidade Federal de São Paulo
- Luciana Almeida Lopes
- Luciano Lauria Dib🇧🇷Universidade Paulista
- Arnaldo Guilherme🇧🇷Universidade Federal de São Paulo
- Eliana Maria Monteiro Caran🇧🇷Support group for adolescents and children with cancer; Universidade Federal de São Paulo
- Adriana Delboni Barreto
- Maria Lucia Martinho Lee🇧🇷Support group for adolescents and children with cancer; Universidade Federal de São Paulo
- Antônio Sérgio Petrilli🇧🇷Support group for adolescents and children with cancer; Universidade Federal de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
A pilot clinical study was conducted to evaluate the efficacy and feasibility of low-level laser therapy (LLLT) in the prevention and treatment of chemotherapy (CT)-induced oral mucositis (OM) in young patients.
Background data
Besides compromising the patient's nutrition and well-being, oral mucositis represents a portal of entry into the body for microorganisms present in the mouth, which may lead to sepsis if there is hematological involvement. Oncologic treatment tolerance decreases and systemic complications may arise that interfere with the success of cancer treatment. LLLT appears to be an interesting alternative to other approaches to treating OM, due to its trophic, anti-inflammatory, and analgesic properties.
Materials and methods
Patients undergoing chemotherapy (22 cycles) without mucositis were randomized into a group receiving prophylactic laser-irradiation (group 1), and a group receiving placebo light treatment (group 2). Patients who had already presented with mucositis were placed in a group receiving irradiation for therapeutic purposes (group 3, with 10 cycles of CT). Serum granulocyte levels were taken and compared to the progression of mucositis.
Results
In group 1, most patients (73%) presented with mucositis of grade 0 (p = 0.03 when compared with the placebo group), and 18% presented with grade 1. In group 2, 27% had no OM and did not require therapy. In group 3, the patients had marked pain relief (as assessed by a visual analogue scale), and a decrease in the severity of OM, even when they had severe granulocytopenia.
Conclusion
The ease of use of LLLT, high patient acceptance, and the positive results achieved, make this therapy feasible for the prevention and treatment of OM in young patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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