Vitamin D deficiency and supplementation during pregnancy
Yu CK, Sykes L, Sethi M, Teoh TG, Robinson S
Clinical endocrinology · 128 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Imperial College London
Según 1 financiador declarado.
Publicación
- Publicado
- 2008-09-02 · Clin Endocrinol (Oxf) · vol. 70 · número 5 · págs. 685–690
- Editorial
- Wiley
- Citado
- 207 citas · más que el 97% de estudios similares · 6.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Vitamin K Research Studies · Bone health and osteoporosis research
- Palabras clave
- vitamin D deficiency, vitamin D supplementation, pregnancy, 25-hydroxyvitamin D, cord blood vitamin D, secondary hyperparathyroidism, parathyroid hormone, corrected calcium, maternal vitamin D status
- MeSH
- humans, pregnancy complications, vitamin d deficiency, vitamin d, prospective studies, pregnancy, adolescent, adult, middle aged, infant, newborn, female, young adult
5 autores
- Chang-Sik Yu🇬🇧 · autor de correspondenciaSt Mary's Hospital; Imperial College London
- Lynne Sykes
- Mieran Sethi🇬🇧St Mary's Hospital; Imperial College London
- Tiong Ghee Teoh
- S. Robinson🇬🇧St Mary's Hospital; Imperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Vitamin D is essential for skeletal health and prolonged deficiency results in infantile rickets and adult osteomalacia. The aim of this study is to determine the vitamin D status in pregnancy and to evaluate the effects of daily and of single-dose vitamin D supplementation.
Design
A prospective randomized study at St Mary's Hospital London.
Patients
A total of 180 women (Indian Asian, Middle Eastern, Black and Caucasian) were recruited at 27 weeks gestation and randomized into three treatment groups: a single oral dose of 200,000 IU vitamin D, a daily supplement of 800 IU vitamin D from 27 weeks until delivery and a no treatment group.
Measurements
Vitamin D (25-hydroxyvitamin D), PTH and corrected calcium levels in mothers at 27 weeks and at delivery and cord 25-hydroxyvitamin D and corrected calcium levels.
Results
The final maternal 25-hydroxyvitamin D levels were significantly higher in the supplemented group [daily dose (median) 42 (IQR 31-76) nmol/l, stat dose (median) 34 (IQR 30-46) nmol/l vs. median 27 (IQR 27-39) nmol/l in the no treatment; P < 0.0001] and significantly fewer women with secondary hyperparathyroidism in the supplemented group (10% in daily dose vs. 12% in stat dose vs. 27% in the no treatment; P < 0.05). Cord 25-hydroxyvitamin D levels were significantly higher with supplementation [daily dose median 26 (IQR 17-45) nmol/l, stat dose median 25 (IQR 18-34) nmol/l vs. median 17 (IQR 14-22) nmol/l in no treatment; P = 0.001].
Conclusion
Single or daily dose improved 25-hydroxyvitamin D levels significantly. However, even with supplementation, only a small percentage of women and babies were vitamin D sufficient. Further research is required to determine the optimal timing and dosing of vitamin D in pregnancy.
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