Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid
Barceló-Coblijn G, Murphy EJ, Othman R, Moghadasian MH, Kashour T, Friel JK
The American journal of clinical nutrition · 127 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (1P20 RR117699-01)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2008-09-01 · Am J Clin Nutr · vol. 88 · número 3 · págs. 801–809
- Editorial
- Elsevier BV
- Citado
- 192 citas · más que el 99% de estudios similares · 11.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- linseed oil, fish oil, alpha-linolenic acid, omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, docosapentaenoic acid, dietary supplementation, firefighters, cardiovascular risk
- MeSH
- erythrocytes, humans, body weight, weight gain, dietary fats, fatty acids, omega-3, docosahexaenoic acids, linseed oil, fish oils, plant oils, blood pressure, dose-response relationship, drug, adult, middle aged, sunflower oil
6 autores
- Gwendolyn Barceló‐Coblijn🇺🇸University of North Dakota
- Eric J. Murphy🇺🇸University of North Dakota
- Rgia Ali Othman🇺🇸University of North Dakota
- Mohammed H. Moghadasian🇺🇸University of North Dakota
- Tarek Seifaw Kashour🇺🇸University of North Dakota
- James Kenneth Friel🇺🇸 · autor de correspondenciaUniversity of North Dakota
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
An increase in plasma n-3 fatty acid content, particularly eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA), is observed after consumption of fish oil-enriched supplements. Because alpha-linolenic acid (18:3n-3; ALA) is the direct precursor of EPA and DHA, ALA-enriched supplements such as flax may have a similar effect, although this hypothesis has been challenged because of reported low conversion of ALA into DHA.
Objective
To address this question, we designed a clinical trial in which flax oil, fish-oil, and sunflower oil (placebo group) capsules were given to firefighters (n = 62), a group traditionally exposed to cardiovascular disease risk factors.
Design
Firefighters were randomly divided into 6 experimental groups receiving 1.2, 2.4, or 3.6 g flax oil/d; 0.6 or 1.2 g fish oil/d; or 1 g sunflower oil/d for 12 wk. Blood was drawn every 2 wk, and the total phospholipid fatty acid composition of red blood cells was determined.
Results
As expected, fish oil produced a rapid increase in erythrocyte DHA and total n-3 fatty acids. The consumption of either 2.4 or 3.6 g flax oil/d (in capsules) was sufficient to significantly increase erythrocyte total phospholipid ALA, EPA, and docosapentaenoic acid (22:5n-3) fatty acid content. There were no differences among groups in plasma inflammatory markers or lipid profile.
Conclusions
The consumption of ALA-enriched supplements for 12 wk was sufficient to elevate erythrocyte EPA and docosapentaenoic acid content, which shows the effectiveness of ALA conversion and accretion into erythrocytes. The amounts of ALA required to obtain these effects are amounts that are easily achieved in the general population by dietary modification.
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