Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil
Killgore WD, Grugle NL, Killgore DB, Leavitt BP, Watlington GI, McNair S, Balkin TJ
Aviation, space, and environmental medicine · 34 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-09-01 · Aviat Space Environ Med · vol. 79 · número 9 · págs. 867–874
- Editorial
- Aerospace Medical Association
- Citado
- 68 citas · más que el 94% de estudios similares · 5.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sleep and Work-Related Fatigue · Sleep and Wakefulness Research · Coffee research and impacts
- Palabras clave
- sleep deprivation, risk propensity, d-amphetamine, modafinil, caffeine, stimulant medication, cognitive performance, decision-making, risk judgment, sensation seeking, cognitive ability
- MeSH
- humans, sleep deprivation, dextroamphetamine, benzhydryl compounds, caffeine, central nervous system stimulants, risk, risk-taking, cognition, decision making, judgment, intelligence tests, psychometrics, adult, female, male, modafinil
7 autores
- William D. S. Killgore🇺🇸Harvard University; McLean Hospital
- Nancy L. Grugle🇺🇸Walter Reed Army Institute of Research
- Desiree B. Killgore🇺🇸Walter Reed Army Institute of Research
- Brian P. Leavitt🇺🇸Walter Reed Army Institute of Research
- George I. Watlington🇺🇸Walter Reed Army Institute of Research
- Shanelle McNair🇺🇸Walter Reed Army Institute of Research
- Thomas J. Balkin🇺🇸Walter Reed Army Institute of Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Sleep deprivation alters risk-related judgments, decision-making, and behavioral control. Stimulant medications are used to restore cognitive performance, but their effects on risk-taking and judgment in sleep-deprived subjects have not been explored.
Methods
There were 54 healthy adults (29 men, 25 women; age range 18 to 36) who completed a test of cognitive ability and daily measures of risk-taking propensity, including the Brief Sensation Seeking Scale (BSSS), Evaluation of Risks (EVAR) scale, and the Balloon Analog RiskTask (BART). Following 44 h of continuous wakefulness, participants ingested caffeine 600 mg (N = 12), dextroamphetamine 20 mg (N = 16), modafinil 400 mg (N = 12), or a placebo (N = 14) in a double blind manner, and completed risk-taking measures 2 h later (i.e., 0535).
Results
Relative to rested baseline, the placebo group showed a decline in risk-taking as measured by the BSSS (16% decline), EVAR Danger Seeking (32% decline) and Energy (22% decline), and BART (32% decline), consistent with previous reports of the effects of sleep deprivation. Comparisons among drug conditions showed that dextroamphetamine restored risk-taking propensity and risky behavior to baseline levels, an effect that was significantly greater than placebo or caffeine for several indices of risk-taking, but which did not differ from modafinil. Cognitive ability was significantly correlated with changes on some risk-taking indices following stimulant administration.
Conclusions
Stimulant medications, particularly dextroamphetamine, sustained risk-related attitudes and behavior during continuous wakefulness. The extent to which stimulants restore other aspects of judgment during sleep loss remains to be determined.
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