Effect of calcium and vitamin D supplementation on blood pressure: the Women's Health Initiative Randomized Trial
Margolis KL, Ray RM, Van Horn L, Manson JE, Allison MA, Black HR, Beresford SA, Connelly SA, Curb JD, Grimm RH, Kotchen TA, Kuller LH, Wassertheil-Smoller S, Thomson CA, Torner JC, Women's Health Initiative Investigators
Hypertension (Dallas, Tex. : 1979) · 165 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- U.S. Public Health Service
- Gobierno
- PHS HHS
- Gobierno
- WHI NIH HHS
- Subvenciones
- U.S. Public Health Service (44221); U.S. Public Health Service (32122); U.S. Public Health Service (24152); U.S. Public Health Service (2105-32106); U.S. Public Health Service (32111-32113); U.S. Public Health Service (42107-42126); U.S. Public Health Service (32108-32109); U.S. Public Health Service (42129-42132); U.S. Public Health Service (32115); National Institutes of Health (N01 WH022110); U.S. Public Health Service (32100-32102)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2008-09-30 · Hypertension · vol. 52 · número 5 · págs. 847–855
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 251 citas · más que el 100% de estudios similares · 17.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Blood Pressure and Hypertension Studies · Nutrition and Health Studies
- Palabras clave
- calcium supplementation, vitamin D supplementation, vitamin D3, blood pressure, hypertension incidence, postmenopausal women, systolic blood pressure, diastolic blood pressure, non-compliance
- MeSH
- humans, hypertension, calcium, vitamin d, incidence, risk factors, longitudinal studies, follow-up studies, patient compliance, blood pressure, dose-response relationship, drug, dietary supplements, aged, middle aged, female
15 autores
- Karen L. Margolis🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Roberta M. Ray🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Linda Van Horn🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- JoAnn E. Manson🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Matthew Allison🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Henry Richard Black🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Shirley A.A. Beresford🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Stephanie A. Connelly🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- J. David Curb🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Richard H. Grimm🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Theodore A. Kotchen🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Lewis H. Kuller🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Sylvia W Wassertheil-Smoller🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- Cynthia A. Thomson🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
- James C. Torner🇺🇸Northwestern University; Brigham and Women's Hospital; University of California San Diego; Fred Hutch Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Experimental and epidemiological studies suggest that calcium and vitamin D supplements may lower blood pressure. We examined the effect of calcium plus vitamin D supplementation on blood pressure and the incidence of hypertension in postmenopausal women. The Women's Health Initiative Calcium/Vitamin D Trial randomly assigned 36 282 postmenopausal women to receive 1000 mg of elemental calcium plus 400 IU of vitamin D3 daily or placebo in a double-blind fashion. Change in blood pressure and the incidence of hypertension were ascertained. Over a median follow-up time of 7 years, there was no significant difference in the mean change over time in systolic blood pressure (0.22 mm Hg; 95% CI: -0.05 to 0.49 mm Hg) and diastolic blood pressure (0.11 mm Hg; 95% CI: -0.04 to 0.27 mm Hg) between the active and placebo treatment groups. This null result was robust in analyses accounting for nonadherence to study pills and in baseline subgroups of interest, including black subjects and women with hypertension or high levels of blood pressure, with low intakes of calcium and vitamin D or low serum levels of vitamin D. In 17 122 nonhypertensive participants at baseline, the hazard ratio for incident hypertension associated with calcium/vitamin D treatment was 1.01 (95% CI: 0.96 to 1.06.) In postmenopausal women, calcium plus vitamin D3 supplementation did not reduce either blood pressure or the risk of developing hypertension over 7 years of follow-up.
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