Manipulation of lipid bioaccessibility of almond seeds influences postprandial lipemia in healthy human subjects
Berry SE, Tydeman EA, Lewis HB, Phalora R, Rosborough J, Picout DR, Ellis PR
The American journal of clinical nutrition · 82 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-10-01 · Am J Clin Nutr · vol. 88 · número 4 · págs. 922–929
- Editorial
- Elsevier BV
- Citado
- 130 citas · más que el 94% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Food composition and properties · Fatty Acid Research and Health
- Palabras clave
- almond seeds, lipid bioaccessibility, postprandial lipemia, plant cell wall, lipid encapsulation, almond oil, sunflower oil, plasma triglycerides, postprandial blood glucose, peripheral vascular tone, oxidative stress, 8-isoprostane, insulin, healthy men
- MeSH
- endothelium, vascular, humans, prunus, seeds, insulin, blood glucose, lipids, dietary fats, triglycerides, plant oils, analysis of variance, area under curve, cross-over studies, oxidative stress, biological availability, digestion, intestinal absorption, postprandial period, flour, adult, male, hyperlipidemias, sunflower oil
7 autores
- Sarah E. Berry🇬🇧 · autor de correspondenciaKing's College London
- Elizabeth A. Tydeman🇬🇧King's College London
- Hannah B Lewis🇬🇧King's College London
- Ravneet Phalora🇬🇧King's College London
- Jennifer Rosborough🇬🇧King's College London
- David R. Picout🇬🇧King's College London
- Peter R. Ellis🇬🇧King's College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Plant cell walls are known to influence the rate and extent of lipid release from plant food tissues during digestion; however, the effect of cell wall structure on postprandial lipemia is unknown.
Objective
The objective was to investigate the effects of lipid release (bioaccessibility) on postprandial lipemia by comparing lipid encapsulated by cell walls with lipid present as free oil.
Design
A randomized crossover trial (n = 20 men) compared the effects of 3 meals containing 54 g fat provided as whole almond seed macroparticles (WA), almond oil and defatted almond flour (AO), or a sunflower oil blend as control (CO) on postprandial changes in oxidative stress (8-isoprostane F(2)alpha concentrations), vascular tone (peripheral augmentation index), and plasma triacylglycerol, glucose, and insulin concentrations.
Results
The postprandial increase in plasma triacylglycerol was lower [74% and 58% lower incremental area under curve (iAUC)] after the WA meal than after the AO and CO meals (P < 0.001). Increases in plasma glucose concentrations (0-180 min) were significantly higher after the WA meal (iAUC: 114; 95% CI: 76, 153) than after the AO meal (iAUC: 74; 95% CI: 48, 99) (P < 0.05), but no significant differences from the CO meal were observed (iAUC: 88; 95% CI: 66, 109). The peak reductions in peripheral augmentation index after the WA, AO, and CO meals (-9.5%, -10.1%, and -12.6%, respectively, at 2 h) were not significantly different between meals. Plasma 8-isoprostane F(2)alpha and insulin concentrations did not differ significantly between meals.
Conclusions
The bioaccessibility of lipid in almond seeds, which is regulated by the structure and properties of cell walls, plays a primary role in determining postprandial lipemia.
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