Vitamin D and prevention of colorectal adenoma: a meta-analysis
Wei MY, Garland CF, Gorham ED, Mohr SB, Giovannucci E
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 106 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2008-11-01 · Cancer Epidemiol Biomarkers Prev · vol. 17 · número 11 · págs. 2958–2969
- Editorial
- American Association for Cancer Research
- Citado
- 146 citas · más que el 83% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Colorectal Cancer Screening and Detection
- Palabras clave
- vitamin D, 25-hydroxyvitamin D, colorectal adenoma, colorectal cancer prevention, vitamin D intake, recurrent adenoma, advanced adenoma, circulating vitamin D levels
- MeSH
- humans, adenoma, colorectal neoplasms, neoplasm recurrence, local, vitamin d, incidence, risk, chi-square distribution
5 autores
- Melissa Y. Wei🇺🇸Harvard University; Oregon Health & Science University
- Cedric F. Garland🇺🇸University of California San Diego
- Edward Doerr Gorham🇺🇸University of California San Diego; Naval Health Research Center
- Sharif Burgette Mohr🇺🇸University of California San Diego; Naval Health Research Center
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D status is associated inversely with risk of colorectal cancer, but the association with adenoma risk is less clear. This meta-analysis examined the overall relationship between circulating (plasma or serum) 25-hydroxyvitamin D [25(OH)D], vitamin D intake (dietary, supplemental, or total), and colorectal adenoma incidence in published studies.
Methods
A meta-analysis composed of 17 epidemiologic studies [1 cross-sectional, 9 case-control, and 7 cohort or nested case-control studies; 7 on 25(OH)D and 12 on vitamin D intake] published before December 2007 was done to examine the association between circulating 25(OH)D, vitamin D intake, and colorectal adenomas. Summary Peto odds ratios (OR) were computed for overall and stratified analyses.
Results
Circulating 25(OH)D was inversely associated with risk of colorectal adenomas: the OR was 0.70 [95% confidence interval (95% CI), 0.56-0.87] for high versus low circulating 25(OH)D. The highest quintile of vitamin D intake was associated with an 11% marginally decreased risk of colorectal adenomas compared with low vitamin D intake (OR, 0.89; 95% CI, 0.78-1.02). For recurrent adenomas, there was a decreased risk of 12% (95% CI, 0.72-1.07) among individuals with high versus low vitamin D intake. The inverse associations appeared stronger for advanced adenoma [OR, 0.64; 95% CI, 0.45-0.90 for serum 25(OH)D and OR, 0.77; 95% CI, 0.63-0.95 for vitamin D intake], but the number of studies was small.
Conclusions
Both circulating 25(OH)D and vitamin D intake were inversely associated with colorectal adenoma incidence and recurrent adenomas. These results further support a role of vitamin D in prevention of colorectal adenoma incidence and recurrence.
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